4-quinolone antibiotic
Oxford Dictionary of Biochemistry:
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4-quinolone antibiotic
a generic term for any of a wide range of synthetic antibacterial compounds whose molecular structures contain a 4-oxo-1,4-dihydroquinoline or a 4-oxo-1,4-dihydrocinnoline nucleus; e.g. cinoxacin, ciprofloxacin, nalidixic acid, oxolinic acid. Their antibiotic activity derives from interaction with the A subunit of bacterial DNA gyrase (see type II DNA topoisomerase); this results in trapping of bacterial DNA in the complex it forms with the A sububit. Rejoining of the DNA strands broken by the enzyme is thereby arrested.
| 4-pi counter, 4-methylumbelliferyl, 4-hydroxybutyric aciduria | |
| 4E-BP, 4Hyp, 4S |
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4-quinolone antibiotic
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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