5,10-Methylenetetrahydrofolate (5,10-CH2-THF, MTHF) is the substrate used by methylenetetrahydrofolate reductase (MTHFR) to generate 5-methyltetrahydrofolate (5-MTHF). 5,10-CH2-THF is also a coenzyme used in thymidine biosynthesis by thymidylate synthase (FAD).
See also
References
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Enzyme cofactors |
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| Active Forms |
vitamins: TPP / ThDP (B 1) · FMN, FAD (B 2) · NAD+, NADH, NADP+, NADPH (B 3) · Coenzyme A (B 5) · PLP / P5P (B 6) · Biotin (B 7) · THFA / H4FA, DHFA / H2FA, MTHF (B 9) · AdoCbl, MeCbl (B 12) · Ascorbic Acid (C) · Phylloquinone (K 1, Menaquinone (K 2) · Coenzyme F420
non-vitamins: ATP · CTP · SAMe · PAPS · GSH · Coenzyme B · Coenzyme M · Coenzyme Q · Heme / Haem (A, B, C, O) · Lipoic Acid · Methanofuran · Molybdopterin · PQQ · THB / BH4 · THMPT / H4MPT
minerals: Ca2+ · Cu2+ · Fe2+, Fe3+ · Mg2+ · Mn2+ · Mo · Ni2+ · Se · Zn2+
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Major families of biochemicals
Saccharides/Carbohydrates/Glycosides · Amino acids/Peptides/Proteins/Glycoproteins · Lipids/Terpenes/Steroids/Carotenoids · Alkaloids/Nucleobases/Nucleic acids · Cofactors/Phenylpropanoids/Polyketides/Tetrapyrroles |
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Vitamins (A11) |
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D2 ( Ergosterol, Ergocalciferol) · D3 ( 7-Dehydrocholesterol, Previtamin D3, Cholecalciferol, 25-hydroxycholecalciferol, Calcitriol ( 1,25-dihydroxycholecalciferol), Calcitroic acid)
D4 ( Dihydroergocalciferol) · D5 · D analogues ( Dihydrotachysterol, Calcipotriol, Tacalcitol, Paricalcitol)
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| Water soluble |
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B1 ( Thiamine) · B2 ( Riboflavin) · B3 ( Niacin, Nicotinamide) · B5 ( Pantothenic acid, Dexpanthenol, Pantethine) · B6 ( Pyridoxine, Pyridoxal phosphate, Pyridoxamine)
B7 ( Biotin) · B9 ( Folic acid, Dihydrofolic acid, Folinic acid) · B12 ( Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide) · Choline
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