5-Carboxamidotryptamine
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5-Carboxamidotryptamine
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| Systematic (IUPAC) name | |
| 3-(2-aminoethyl)-1H-indole-5-carboxamide | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 74885-09-9 |
| ATC code | ? |
| PubChem | CID 1809 |
| IUPHAR ligand | 4 |
| ChemSpider | 1743  |
| ChEBI | CHEBI:48292 |
| ChEMBL | CHEMBL18840 |
| Chemical data | |
| Formula | C11H13N3O |
| Mol. mass | 203.240 g/mol |
| SMILES | eMolecules & PubChem |
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5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.
5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity.[1][2][3] It has negligible affinity for the 5-HT1E and 5-HT1F receptors.[4] 5-CT binds strongest to the 5-HT1A receptor and it was once thought to be selective for this site.[5][6]
See also
- 2-Methyl-5-hydroxytryptamine
- 5-Benzyloxytryptamine
- 5-Methoxytryptamine
- α-Methyl-5-hydroxytryptamine
- Sumatriptan
References
- ^ Yamada J, Sugimoto Y, Noma T, Yoshikawa T. (1998). "Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.". Eur J Pharmacol. 359 (1): 81–86. doi:10.1016/S0014-2999(98)00617-7. PMID 9831297.
- ^ Wright, CE; Angus, JA (1989). "5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.". Journal of cardiovascular pharmacology 13 (4): 557–64. PMID 2470992.
- ^ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Archived from the original on 21 April 2008. http://www.acnp.org/g4/GN401000039/Ch039.html. Retrieved 2008-04-11.
- ^ Stanton JA, Middlemiss DN, Beer MS. (1996). "Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.". Neuropharmacology. 35 (2): 223–229. doi:10.1016/0028-3908(95)00178-6. PMID 8734492.
- ^ Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). "5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors". British Journal of Pharmacology 128 (1): 158–64. doi:10.1038/sj.bjp.0702759. PMC 1571602. PMID 10498847. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1571602.
- ^ Saxena, PR; Lawang, A (1985). "A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors". Archives internationales de pharmacodynamie et de therapie 277 (2): 235–52. PMID 2933009.
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