5-Fluoro-DMT
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5-Fluoro-DMT
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| Systematic (IUPAC) name | |
| 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 22120-36-1 |
| ATC code | ? |
| PubChem | CID 2762738 |
| ChemSpider | 2043436  |
| Chemical data | |
| Formula | C12H15FN2 |
| Mol. mass | 206.259 g/mol |
| SMILES | eMolecules & PubChem |
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5-Fluoro-N,N-dimethyltryptamine (5-fluoro-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of hallucinogenic tryptamines either reduces or has little effect on 5-HT2A/C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a hallucinogen despite acting as a 5-HT2A agonist (cf. lisuride), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at 5-HT1A than 5-HT2A.[1][2]
See also
- 5-fluoro-AMT
- 6-fluoro-DMT
- 4-fluoro-5-methoxy-DMT
- 6-Fluoro-DET
References
- ^ Blair, JB; Kurrasch-Orbaugh, D; Marona-Lewicka, D; Cumbay, MG; Watts, VJ; Barker, EL; Nichols, DE (2000). "Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines". Journal of Medical Chemistry 43 (24): 4701–10. doi:10.1021/jm000339w. PMID 11101361.
- ^ Rabin, RA; Regina, M; Doat, M; Winter, JC (2002). "5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens". Pharmacology, Biochemistry, and Behavior 72 (1–2): 29–37. doi:10.1016/S0091-3057(01)00720-1. PMID 11900766.
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