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| Crystallographic structure of the inhibitor-bound human 5-lipoxygenase-activating protein.[1] | |
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arachidonate 5-lipoxygenase-activating protein
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| Identifiers | |
| Symbol | ALOX5AP |
| Entrez | 241 |
| HUGO | 436 |
| OMIM | 603700 |
| RefSeq | NM_001629 |
| UniProt | P20292 |
| Other data | |
| Locus | Chr. 13 q12 |
5-Lipoxygenase activating protein, or FLAP, is an enzyme necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes.[2] It is bound to the nuclear membrane. FLAP is an integral membrane protein of the nucleus membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consist of 4 transmembrane alpha helices, but they are found in 3’s( trimer) forming a barrel. The barrel is about 60 A high and 36 A wide.[1]
Pathology
Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease.[3] Leukotrienes, which need the FLAP protein to be made,have an established pathological role in allergic and respiratory disease.Leukotrienes have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis. [1]
References
- ^ a b c PDB 2q7r; Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW (July 2007). "Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein". Science (journal) 317 (5837): 510–2. doi:. PMID 17600184.
- ^ Peters-Golden M, Brock TG (2003). "5-lipoxygenase and FLAP". Prostaglandins Leukot Essent Fatty Acids 69 (2-3): 99–109. doi:. PMID 12895592.
- ^ Manev H, Manev R (2006). "5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease". Med Hypotheses 66 (3): 501–3. doi:. PMID 16278051.
External links
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