| Systematic (IUPAC) name | |
|---|---|
| 2-(5-Methoxy-1H-indol-3-yl)ethanamine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 608-07-1 |
| ATC code | ? |
| PubChem | CID 1833 |
| IUPHAR ligand | 107 |
| ChemSpider | 1767 |
| KEGG | C05659 |
| ChEBI | CHEBI:2089 |
| ChEMBL | CHEMBL8165 |
| Chemical data | |
| Formula | C11H14N2O |
| Mol. mass | 190.242 g/mol |
| SMILES | eMolecules & PubChem |
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5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.[1] It is biosynthesized via the deacetylation of melatonin in the pineal gland.[1]
5-MT acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.[2][3][4][5][6][7][8] It has no affinity for the 5-HT3 receptor and it should also be noted that its affinity for the 5-HT1E receptor is very weak in comparison to the other 5-HT1 receptors.[5][9] Its affinity for the 5-HT5A receptor is unknown.
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