5S ribosomal RNA
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5S ribosomal RNA
| 5S ribosomal RNA | |
|---|---|
 |
|
| Predicted secondary structure and sequence conservation of 5S ribosomal RNA | |
| Identifiers | |
| Symbol | 5S_rRNA |
| Rfam | RF00001 |
| Other data | |
| RNA type | Gene; rRNA |
| Domain(s) | Eukaryota; Bacteria; Archaea |
| GO | 0005840 0003735 |
| SO | 0000652 |
5S ribosomal RNA (5S rRNA) is a component of the large ribosomal subunit in both prokaryotes (50S) and eukaryotes (60S).
Eukaryotic 5S rRNA is synthesised by RNA polymerase III, whereas most other eukaroytic rRNAs are cleaved from a 45S precursor transcribed by RNA polymerase I. In Xenopus oocytes, it has been shown that fingers 4-7 of the nine-zinc finger transcription factor TFIIIA can bind to the central region of 5S RNA.[3] Binding between 5S rRNA and TFIIIA serves to both repress further transcription of the 5S RNA gene and stabilize the 5S RNA transcript until it is required for ribosome assembly.[4]
References
- ^ Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R (2000). "The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution.". J Mol Biol 298 (1): 35–59. doi:10.1006/jmbi.2000.3635. PMID 10756104.
- ^ Mitra K, Schaffitzel C, Fabiola F, Chapman MS, Ban N, Frank J (2006). "Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements.". Mol Cell 22 (4): 533–43. doi:10.1016/j.molcel.2006.05.003. PMID 16713583.
- ^ Searles, MA; Lu D, Klug A (2000). "The role of the central zinc fingers of transcription factor IIIA in binding to 5 S RNA". J Mol Biol 301 (1): 47–60. doi:10.1006/jmbi.2000.3946. PMID 10926492.
- ^ Pelham, HRB; Brown DD (1980). "A specific transcription factor that can bind either the 5S RNA gene or 5S RNA". Proc. Natl. Acad. Sci. USA 77 (7): 4170–4174. doi:10.1073/pnas.77.7.4170. PMC 349792. PMID 7001457. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=349792.
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