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6-Fluoronorepinephrine

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6-Fluoronorepinephrine

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6-Fluoronorepinephrine
Systematic (IUPAC) name
4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
Clinical data
Pregnancy cat.  ?
Legal status Uncontrolled
Identifiers
CAS number 86820-21-5
ATC code None
PubChem CID 1862
IUPHAR ligand 510
ChemSpider 1792 YesY
ChEMBL CHEMBL281232 YesY
Chemical data
Formula C8H10FNO3 
Mol. mass 187.17 g/mol
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]

References

  1. ^ a b Kirk KL, Cantacuzene D, Nimitkitpaisan Y, et al. (December 1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry 22 (12): 1493–7. doi:10.1021/jm00198a012. PMID 231654. 
  2. ^ a b c Stone EA, Lin Y, Sarfraz Y, Quartermain D (September 2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist". Brain Research 1291: 21–31. doi:10.1016/j.brainres.2009.07.049. PMID 19632210. http://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01470-X. 
  3. ^ Stone EA, Grunewald GL, Lin Y, et al. (July 2003). "Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice". Synapse (New York, N.Y.) 49 (1): 67–76. doi:10.1002/syn.10212. PMID 12710017. 
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Stimulants: 2-OH-PEA • β-Me-PEA • Hordenine • N-Me-PEA • Phenethylamine (PEA)
Entactogens: Lophophine • MDPEA • MDMPEA
Others: BOH • DMPEA
Amphetamines
Phenylisopropylamines
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Entactogens: 5-APDB • 6-APB • 6-APDB • EDA • IAP • MDA • MDEA • MDHMA (FLEA) • MDMA ("Ecstasy") • MDOH • MMDMA • NAP • TAP
Others: Amiflamine • DFMDA • D-Deprenyl • L-Deprenyl (Selegiline)
Phentermines
Stimulants: Chlorphentermine • Cloforex • Clortermine • Etolorex • Mephentermine • Pentorex (Phenpentermine) • Phentermine
Entactogens: MDPH • MDMPH
Cathinones
Stimulants: Amfepramone • Brephedrone • Buphedrone • Bupropion (Amfebutamone) • Cathinone (Propion) • Dimethylcathinone (Dimethylpropion, Metamfepramone) • Ethcathinone (Ethylpropion) • Flephedrone • Methcathinone (Methylpropion) • Mephedrone • Methedrone
Entactogens: Ethylone • Methylone
Phenylisobutylamines
Entactogens: 4-CAB • 4-MAB • Ariadne (α-Et-DOM) • BDB (J) • Butylone (bk-MBDB) • EBDB (Ethyl-J) • Eutylone (bk-EBDB) • MBDB (Methyl-J)
Stimulants: Phenylisobutylamine
Phenylalkylpyrrolidines
Stimulants: α-PBP • α-PPP • α-PVP • MDPBP • MDPPP • MDPV • MOPPP • MPBP • MPHP • MPPP • Naphyrone • PEP • Prolintane • Pyrovalerone
Catecholamines
(and relatives..)
6-FNE • 6-OHDA • α-Me-DA • α-Me-TRA • Adrenochrome • Ciladopa • D-DOPA (Dextrodopa) • Dopamine • Epinephrine (Adrenaline) • Epinine • Fenclonine • Ibopamine • L-DOPA (Levodopa) • L-DOPS (Droxidopa) • L-Phenylalanine • L-Tyrosine • meta-Octopamine • meta-Tyramine • Metanephrine • Metirosine • Methyldopa • Nordefrin (Levonordefrin) • Norepinephrine (Noradrenaline) • Normetanephrine • para-Octopamine • para-Tyramine
Miscellaneous

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