77-LH-28-1
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77-LH-28-1
| 77-LH-28-1 | |
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1-[3-(4-Butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone |
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| Identifiers | |
| CAS number | 560085-11-2  |
| PubChem | 10236758 |
| ChemSpider | 8412246 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C21H32N2O |
| Molar mass | 328.49 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
77-LH-28-1 is a recently discovered selective agonist of muscarinic acetylcholine receptor subtype 1 (M1). It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood brain barrier and is therefore a useful pharmocologic tool with cognition enhancing effects.[1]
References
- ^ C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2451039.
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