| 8-Azaguanine | |
|---|---|
 |
|
| IUPAC name | |
| Identifiers | |
| CAS number | 134-58-7  |
| PubChem | 8646 |
| RTECS number | XZ6157000 |
| SMILES |
C12=NNNC1=NC(=NC2=O)N
|
| Properties | |
| Molecular formula | C4H4N6O |
| Molar mass | 152.11 g mol−1 |
| Appearance | white to off-white crystalline powder[4] |
| Density | 2.64 g/cm³ |
| Melting point |
> 300 °C (decomp.) |
| Solubility in water | Insoluble |
| Hazards | |
| Flash point | 129.1 °C |
| (what is this?) (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
8-Azaguanine is a purine analog with the chemical formula C4H4N6O. It has been widely studied for its biological activity.[5] It shows antineoplastic activity and has been used in the treatment of acute leukemia.[2]
Contents |
Use in chemotherapy
The compound closely resembles guanine and appears to be competitive with it in the metabolism of living organisms.[6] It has been shown to cause retardation of some malignant neoplasms when administered to tumors in animals.[6] 8-Azaguanine was the first purine analogue discovered to inhibit experimental tumors in mice.[7]
Synonyms
|
|
References
- ^ "Azaguanine - Compound Summary (Descriptors)". National Center for Biotechnology Information. 27 March 2005. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8646#Descriptors. Retrieved 2009-03-03.
- ^ a b "8-azaguanine". Mondofacto. 12 December 1998. http://www.mondofacto.com/facts/dictionary?azaguanine. Retrieved 2009-03-03.
- ^ a b http://www.chemindustry.com/chemicals/747854.html Retrieved on 2009-03-03.
- ^ "8-AZAGUANINE". ChemicalLAND21.com. http://chemicalland21.com/lifescience/phar/8-AZAGUANINE.htm. Retrieved 2009-03-03.
- ^ Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965), "Synthesis of some 2′-deoxyribosides of 8-azaadenine", Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76, doi:
- ^ a b Colsky, J.; Meiselas, E.L.; Rosen, J.S.; Schulman, I. (1955), "Response of patients with leukemia to 8-azaguanine", Blood 10 (5): 482–92, PMID 14363328, http://bloodjournal.hematologylibrary.org/cgi/reprint/10/5/482.pdf
- ^ Timmis, G.M.; Williams, Donald Charles (1967), Chemotherapy of Cancer: the Antimetabolite Approach: The Antimetabolite Approach, University of Michigan: Butterworths, p. 36
- ^ http://www.chemcas.com/msds/cas/msds137/134-58-7.asp Retrieved on 2009-03-03.
- ^ "Azaguanine - Compound Summary (Synonyms)". National Center for Biotechnology Information. 27 March 2005. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8646&ncount=73#Synonyms. Retrieved 2009-03-03.
External links
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
