8-Phenyltheophylline
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8-Phenyltheophylline
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| Systematic (IUPAC) name | |
| 8-phenyl-1,3-dimethyl-7H-purine-2,6-dione | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 961-45-5  |
| ATC code | ? |
| PubChem | CID 1922 |
| ChemSpider | 1846  |
| ChEMBL | CHEMBL62350 |
| Chemical data | |
| Formula | C13H12N4O2 |
| Mol. mass | 256.259 g/mol |
| SMILES | eMolecules & PubChem |
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8-Phenyltheophylline (8-Phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A1 and A2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor.[1][2][3] It has stimulant effects in animals with similar potency to caffeine.[4] Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.[5]
See also
References
- ^ Scotini E, Carpenedo F, Fassina G (February 1983). "New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities". Pharmacological Research Communications 15 (2): 131–43. PMID 6844374.
- ^ Rabe KF, Magnussen H, Dent G (April 1995). "Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants". The European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology 8 (4): 637–42. PMID 7664866.
- ^ Howell LL, Morse WH, Spealman RD (September 1990). "Respiratory effects of xanthines and adenosine analogs in rhesus monkeys". The Journal of Pharmacology and Experimental Therapeutics 254 (3): 786–91. PMID 2395111.
- ^ Spealman RD (1988). "Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism". Psychopharmacology 95 (1): 19–24. PMID 3133696.
- ^ Murray S, Odupitan AO, Murray BP, Boobis AR, Edwards RJ (March 2001). "Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline". Xenobiotica 31 (3): 135–51. doi:10.1080/00498250110043292. PMID 11465391.
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