8A-PDHQ: Information from Answers.com

8A-PDHQ
Systematic (IUPAC) name

8a-phenyldecahydroquinoline
Identifiers
CAS number	131556-11-1
ATC code	?
PubChem	131397
ChemSpider	116144
Chemical data
Formula	C₁₅H₂₁N
Mol. mass	215.3339 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist. It is a structural analog of Phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.^[1]^[2]

References

^ Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP (1992). "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". J Med Chem 35 (9): 1634–8. doi:10.1021/jm00087a020.
^ Elhallaoui M, Laguerre M, Carpy A, Ouazzani FC (2002). "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". J Mol Model 8 (2): 65–72. doi:10.1007/s00894-001-0067-4.

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Hallucinogens

Psychedelics
5-HT_2AR Agonists

Lysergamides: AL-LAD • ALD-52 • BU-LAD • CYP-LAD • Diallyllysergamide • DAM-57 • Ergonovine • ETH-LAD • LAE-32 • LSD • LPD-824 • LSM-775 • D-Lysergic acid N-(α-hydroxyethyl)amide • Lysergic acid 2-butyl amide • Lysergic acid 2,4-dimethylazetidide • Methylergonovine • Methylisopropyllysergamide • MLD-41 • PARGY-LAD • PRO-LAD;

Phenethylamines: Aleph • 2C-B • 2C-B-FLY • 2CBFly-NBOMe • 2C-C • 2C-D • 2C-E • 2C-F • 2C-G • 2C-I • 2C-N • 2C-O • 2C-O-4 • 2C-P • 2C-T • 2C-T-2 • 2C-T-4 • 2C-T-7 • 2C-T-8 • 2C-T-9 • 2C-T-13 • 2C-T-15 • 2C-T-17 • 2C-T-21 • 2C-TFM • 2C-YN • 2CBCB-NBOMe • 25B-NBOMe • 25I-NBMD • 25I-NBOH • 25I-NBOMe • 3C-E • 3C-P • Br-DFLY • DESOXY • DMMDA-2 • DOB • DOC • DOEF • DOET • DOF • DOI • DOM • DON • DOPR • DOTFM • Escaline • Ganesha • HOT-2 • HOT-7 • HOT-17 • Isoproscaline • Jimscaline • Lophophine • MDA • MDEA • MDMA • MMDA • MMDA-2 • MMDA-3a • MMDMA • Macromerine • Mescaline • Methallylescaline • Myristicin • Proscaline • TCB-2 • TFMFly • TMA;

Piperazines: pFPP • TMFPP;

Tryptamines: 1-Methyl-5-methoxy-diisopropyltryptamine • 2,N,N-TMT • 4,N,N-TMT • 4-HO-5-MeO-DMT • 4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-Acetoxy-DPT • 4-Acetoxy-MiPT • 4-HO-DPT • 4-HO-MET • 4-Propionyloxy-DMT • 4-Hydroxy-N-Methyl-(α,N-trimethylene)tryptamine • 5-Me-MIPT • 5-N,N-TMT • 5-AcO-DMT • 5-MeO-2,N,N-TMT • 5-MeO-4,N,N-TMT • 5-MeO-α,N,N-TMT • 5-MeO-α-ET • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-EiPT • 5-MeO-MET • 5-MeO-MIPT • 5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine • 7,N,N-TMT • α,N,N-TMT • α-ET • α-MT • AL-37350A • Baeocystin • Bufotenin • DBT • DET • DIPT • DMT • DPT • EiPT • Ethocin • Ethocybin • Iprocin • MET • Miprocin • MIPT • Norbaeocystin • PiPT • Psilocin • Psilocybin;

Others: AL-38022A • Ibogaine • Noribogaine • Voacangine

Dissociatives
NMDAR Antagonists

Adamantanes: Amantadine • Memantine • Rimantadine;

Arylcyclohexylamines: Dieticyclidine • Esketamine • Eticyclidine • Gacyclidine • Ketamine • Neramexane • Phencyclidine • Rolicyclidine • Tenocyclidine • Tiletamine;

Morphinans: Dextromethorphan • Dextrorphan • Methorphan / Racemethorphan • Morphan / Racemorphan;

Others: 2-MDP • 8A-PDHQ • Aptiganel • Dexoxadrol • Dizocilpine / MK-801 • Etoxadrol • Ibogaine • Midafotel • NEFA • Nitrous Oxide • Noribogaine • Perzinfotel • Remacemide • Selfotel • Xenon

Deliriants
mAChR Antagonists

3-Quinuclidinyl benzilate • Atropine • Benactyzine • Benzatropine • Benzydamine • Biperiden • Brompheniramine • CAR-226,086 • CAR-301,060 • CAR-302,196 • CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • Chlorpheniramine • Chloropyramine • Clemastine • CS-27349 • Cyclizine • Cyproheptadine • Dicyclomine / Dicycloverine • Dimenhydrinate • Diphenhydramine • Ditran • Doxylamine • EA-3167 • EA-3443 • EA-3580 • EA-3834 • Flavoxate • Hydroxyzine • Hyoscyamine • Meclizine • N-Ethyl-3-piperidyl benzilate • N-Methyl-3-piperidyl benzilate • Pyrilamine • Orphenadrine • Oxybutynin • Pheniramine • Phenyltoloxamine • Procyclidine • Promethazine • Scopolamine / Hyoscine • Tolterodine • Trihexyphenidyl • Tripelennamine • Triprolidine • WIN-2299

Miscellaneous
Atypicals

Cannabinoids CB₁R Agonists	Cannabinol • CP-47,497 • CP-55,244 • CP-55,940 • DMHP • HU-210 • JWH-018 • JWH-030 • JWH-073 • JWH-081 • JWH-200 • JWH-250 • Nabilone • Nabitan • Nantradol • Parahexyl • THC / Dronabinol • WIN-55,212-2

Inhalants Mixed MOA	Acetone • Butane • Chloroform • Diethyl Ether / Ether • Enflurane • Freon • Gasoline / Petrol • Kerosene / Paraffin • Propane

Narcotics κOR Agonists	2-EMSB • 2-MMSB • Alazocine • Bremazocine • Butorphanol • Cyclazocine • Cyprenorphine • Dezocine • Enadoline • Herkinorin • HZ-2 • Ibogaine • Ketazocine • Metazocine • Nalbuphine • Nalorphine • Noribogaine • Pentazocine • Phenazocine • Salvinorin A • Spiradoline • Tifluadom • U-50488

Tranquilizers GABA_AR Agonists	Eszopiclone • Gaboxadol • Ibotenic Acid • Muscimol • Zaleplon • Zolpidem • Zopiclone

Others	Efavirenz • Glaucine • Isoaminile • Narcotine / Noscapine

Glutamatergics

Ionotropic

AMPA	Agonists: 5-Fluorowillardiine • AMPA • Domoic Acid • Quisqualic Acid; Positive Allosteric Modulators: Aniracetam • Cyclothiazide • CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-392,098 • LY-404,187 • LY-451,395 • LY-451,646 • LY-503,430 • Oxiracetam • PEPA • Piracetam • Pramiracetam • Sunifiram • Unifiram Antagonists: ATPO • Caroverine • CNQX • DNQX • GYKI-52466 • NBQX • Perampanel • Tezampanel (LY-293,558); Negative Allosteric Modulators: GYKI-53,655

NMDA	Agonists: Glutamate/Acite Site Competitive Agonists: Aspartate • Glutamate • Homoquinolinic Acid • Ibotenic Acid • NMDA • Quinolinic Acid • Tetrazolylglycine; Glycine Site Agonists: ACBD • ACPC • ACPD • Alanine • CCG • Cycloserine • DHPG • Fluoroalanine • Glycine • HA-966 • L-687,414 • Milacemide • Sarcosine • Serine • Tetrazolylglycine; Polyamine Site Agonists: Acamprosate • Spermidine • Spermine Antagonists: Competitive Antagonists: AP5 (APV) • AP7 • CGP-37849 • CGP-39551 • CGP-39653 • CGP-40116 • CGS-19755 • CPP • LY-233,053 • LY-235,959 • LY-274,614 • MDL-100,453 • Midafotel (d-CPPene) • NPC-12,626 • NPC-17,742 • PBPD • PEAQX • Perzinfotel • PPDA • SDZ-220581 • Selfotel (CGS-19,755); Noncompetitive Antagonists: ARR-15,896 • Caroverine • Dexanabinol (HU-211) • FPL-12495 • FR-115,427 • Hodgkinsine • Magnesium • MDL-27,266 • NPS-1506 • Psychotridine • Zinc; Uncompetitive Pore Blockers: 2-MDP • 8A-PDHQ • Amantadine • Aptiganel (CNS-1102) • ARL-12,495 • ARL-15,896-AR • ARL-16,247 • Budipine • Delucemine • Dexoxadrol • Dieticyclidine • Dizocilpine (MK-801) • Endopsychosin • Esketamine • Etoxadrol • Eticyclidine • Gacyclidine • Ibogaine • Indantadol (CHF-3381) • Ketamine • Ketobemidone • Loperamide • Memantine • Meperidine (Pethidine) • Methadone • Methorphan (Dextromethorphan, Levomethorphan) • Milnacipran • Morphanol (Dextrorphan, Levorphanol) • NEFA • Neramexane • Nitrous Oxide • Noribogaine • Orphenadrine • Phencyclamine • Phencyclidine • Propoxyphene • Remacemide • Rhynchophylline • Riluzole • Rimantadine • Rolicyclidine • Tenocyclidine • Tiletamine • Tramadol • Xenon; Glycine Site Antagonists: ACEA-1021 • ACEA-1328 • ACPC • Carisoprodol • CGP-39653 • CKA • DCKA • Felbamate • Gavestinel (GV-150,526) • GV-196,771 • Kynurenic Acid • L-689,560 • L-701,324 • Lacosamide • Licostinel (ACEA-1021) • LU-73,068 • MDL-105,519 • Meprobamate • MRZ 2/576 • PNQX • ZD-9379; NR2B Subunit Antagonists: Besonprodil • CO-101,244 (PD-174,494) • CP-101,606 • Eliprodil • Haloperidol • Ifenprodil • Isoxsuprine • Nylidrin • Ro8-4304 • Ro25-6981 • Traxoprodil; Polyamine Site Antagonists: Arcaine • Co 101676 • Diaminopropane • Diethylenetriamine • Huperzine A • Putrescine • Ro 25-6981; Unclassified/Unsorted Antagonists: Chloroform • Diethyl Ether • Enflurane • Ethanol (Alcohol) • Halothane • Isoflurane • Methoxyflurane

Kainate	Agonists: 5-Iodowillardiine • ATPA • Domoic Acid • Kainate • LY-339,434 • SYM-2081 Antagonists: CNQX • DNQX • LY-382,884 • NBQX • NS102 • UBP-302; Negative Allosteric Modulators: NS-3763

Metabotropic

Group I	Agonists: Unselective: ACPD • DHPG • Quisqualic Acid; mGlu1-Selective: Ro01-6128 • Ro67-4853 • Ro67-7476 • VU-71; mGlu5-Selective: ADX-47273 • CDPPB • CHPG • DFB • VU-1545 Antagonists: Unselective: MCPG • NPS-2390; mGlu1-Selective: BAY 36-7620 • CPCCOEt • LY-367,385 • LY-456,236; mGlu5-Selective: DMeOB • Fenobam • LY-344,545 • MPEP • MTEP • SIB-1757 • SIB-1893

Group II	Agonists: Unselective: CBiPES • DCG-IV • Eglumegad (LY-354,740) • LY-379,268 • LY-404,039 • LY-487,379 • MGS-0028; mGlu2-Selective: BINA • LY-566,332 Antagonists: Unselective: APICA • EGLU • HYDIA • LY-307,452 • LY-341,495 • MCPG: mGlu2-Selective: PCCG-4; mGlu3-Selective: CECXG

Group III	Agonists: Unselective: L-AP4; mGlu4-Selective: PHCCC • VU-001,171 • VU-0155,041; mGlu7-Selective: AMN082; mGlu8-Selective: DCPG Antagonists: Unselective: CPPG • MAP4 • MSOP • MPPG • MTPG • UBP-1112; mGlu7-Selective: MMPIP

Transporter
Inhibitors

EAATs	DHKA • PDC • WAY-213,613

vGluTs	7-CKA • Evans Blue

TRPC6	Adhyperforin • Hyperforin

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