9-Aminomethyl-9,10-dihydroanthracene
Wikipedia on Answers.com:
Top
9-Aminomethyl-9,10-dihydroanthracene
 |
|
|---|---|
| Systematic (IUPAC) name | |
| 9-Aminomethyl-9,10-dihydroanthracene | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 22136-76-1 |
| ATC code | ? |
| PubChem | CID 10398175 |
| ChemSpider | 8573613  |
| ChEMBL | CHEMBL47482 |
| Chemical data | |
| Formula | C15H15N |
| Mol. mass | 209.286 g/mol |
| SMILES | eMolecules & PubChem |
|
|
 (what is this?) (verify) |
|
AMDA (9-Aminomethyl-9,10-dihydroanthracene) is an organic compound which acts as a potent and selective antagonist for the 5-HT2A receptor.[1] It has been used to help study the shape of the 5-HT2A protein,[2] and develop a large family of related derivatives with even higher potency and selectivity.[3][4][5][6][7]
References
- ^ Westkaemper, RB; Runyon, SP; Bondarev, ML; Savage, JE; Roth, BL; Glennon, RA (1999). "9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist". European Journal of Pharmacology 380 (1): R5–7. doi:10.1016/S0014-2999(99)00525-7. PMID 10513561.
- ^ Runyon, SP; Peddi, S; Savage, JE; Roth, BL; Glennon, RA; Westkaemper, RB (2002). "Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene". Journal of Medical Chemistry 45 (8): 1656–64. doi:10.1021/jm010354g. PMID 11931619.
- ^ Peddi, S; Roth, BL; Glennon, RA; Westkaemper, RB (2003). "Spiro9,10-dihydroanthracene-9,3'-pyrrolidine-a structurally unique tetracyclic 5-HT2A receptor antagonist". European Journal of Pharmacology 482 (1–3): 335–7. doi:10.1016/j.ejphar.2003.09.059. PMID 14660041.
- ^ Peddi, S; Roth, BL; Glennon, RA; Westkaemper, RB (2004). "Structural determinants for high 5-HT(2A) receptor affinity of spiro9,10-dihydroanthracene-9,3(')-pyrrolidine (SpAMDA)". Bioorganic & Medicinal Chemistry Letters 14 (9): 2279–83. doi:10.1016/j.bmcl.2004.02.014. PMID 15081025.
- ^ Dewkar, GK; Peddi, S; Mosier, PD; Roth, BL; Westkaemper, RB (2008). "Methoxy-substituted 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives Exhibit Differential Binding Affinities at the 5-HT2A Receptor". Bioorganic & Medicinal Chemistry Letters 18 (19): 5268–71. doi:10.1016/j.bmcl.2008.08.059. PMC 3082371. PMID 18774714. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3082371.
- ^ Runyon, SP; Mosier, PD; Roth, BL; Glennon, RA; Westkaemper, RB (2008). "Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation". Journal of Medical Chemistry 51 (21): 6808–28. doi:10.1021/jm800771x. PMC 3088499. PMID 18847250. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3088499.
- ^ Shah JR, Mosier PD, Peddi S, Roth BL, Westkaemper RB (February 2010). "9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites". Bioorganic & Medicinal Chemistry Letters 20 (3): 935–8. doi:10.1016/j.bmcl.2009.12.064. PMID 20045641.
 |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
 |
This article about an amine is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
Wikipedia on Answers.com
This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article 9-Aminomethyl-9,10-dihydroanthracene.
Read more