A-349,821

A-349,821

Systematic (IUPAC) name
(4'-[3-(2R,5R-dimethylpyrrolidin-1-yl)propoxy]biphenyl-4-yl)morpholin-4-ylmethanone
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 9954017
IUPHAR ligand	1217
ChemSpider	8129627 Y
ChEMBL	CHEMBL179702 Y
Chemical data
Formula	C26H34N2O3
Mol. mass	422.558
SMILES	eMolecules & PubChem
InChI InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m1/s1 Y Key:CFUHKRLMDNFZED-NHCUHLMSSA-N Y
Y (what is this?)  (verify)

A-349,821 is a potent and selective histamine H₃ receptor antagonist^[1] (or possibly an inverse agonist).^[2] It has nootropic effects in animal studies,^[3] although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.

See also

H3 receptor antagonist

References

1. ^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K et al (2003). "Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists". Bioorganic & Medicinal Chemistry Letters 13 (7): 1325–8. doi:10.1016/S0960-894X(03)00118-5. PMID 12657274. 
2. ^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW et al (2006). "Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand". British Journal of Pharmacology 148 (5): 657–70. doi:10.1038/sj.bjp.0706752. PMC 1751875. PMID 16715122. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1751875. 
3. ^ Esbenshade, TA; Fox, GB; Krueger, KM; Baranowski, JL; Miller, TR; Kang, CH; Denny, LI; Witte, DG et al (2004). "Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist". Biochemical pharmacology 68 (5): 933–45. doi:10.1016/j.bcp.2004.05.048. PMID 15294456. 

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