A-412,997
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A-412,997
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| Systematic (IUPAC) name | |
| N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| PubChem | CID 10425450 |
| ChemSpider | 8600878  |
| ChEMBL | CHEMBL375596 |
| Chemical data | |
| Formula | C19H23N3O |
| Mol. mass | 309.405 g/mol |
| SMILES | eMolecules & PubChem |
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A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269.[1] In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability.[2][3] Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.[4]
References
- ^ Moreland, RB; Patel, M; Hsieh, GC; Wetter, JM; Marsh, K; Brioni, JD (2005). "A-412997 is a selective dopamine D4 receptor agonist in rats". Pharmacology, Biochemistry, and Behavior 82 (1): 140–7. doi:10.1016/j.pbb.2005.08.001. PMID 16153699.
- ^ Browman, KE; Curzon, P; Pan, JB; Molesky, AL; Komater, VA; Decker, MW; Brioni, JD; Moreland, RB et al (2005). "A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats". Pharmacology, Biochemistry, and Behavior 82 (1): 148–55. doi:10.1016/j.pbb.2005.08.002. PMID 16154186.
- ^ Woolley ML, Waters KA, Reavill C, Bull S, Lacroix LP, Martyn AJ, Hutcheson DM, Valerio E et al (December 2008). "Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat". Behavioural Pharmacology 19 (8): 765–76. doi:10.1097/FBP.0b013e32831c3b06. PMID 19020411.
- ^ Osinski, MA; Uchic, ME; Seifert, T; Shaughnessy, TK; Miller, LN; Nakane, M; Cox, BF; Brioni, JD et al (2005). "Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets". Pharmacology, Biochemistry, and Behavior 81 (1): 211–9. doi:10.1016/j.pbb.2005.03.012. PMID 15894081.
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