If no Vice Presidential appointment has been confirmed by Congress before the second individual resigns, the presidency goes to the holder of the office that is highest on the list below who is qualified, willing and able to perform the duties of the presidency.
- The Speaker of the U. S. House of Representatives
- The President Pro Tempore of the U. S. Senate
- The U. S. Secretary of State
- The U. S. Secretary of the Treasury
- The U. S. Secretary of Defense
- The U. S. Attorney General
- The U. S. Secretary of the Interior
- The U. S. Secretary of Agriculture
- The U. S. Secretary of Commerce
- The U. S. Secretary of Labor
- The U. S. Secretary of Health and Human Services
- The U. S. Secretary of Education
- The U. S. Secretary of Housing and Urban Development
- The U. S. Secretary of Transportation
- The U. S. Secretary of Energy
- The U. S. Secretary of Veterans Affairs
- The U. S. Secretary of Homeland Security