Abafungin
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Abafungin
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| Systematic (IUPAC) name | |
| N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | topical |
| Identifiers | |
| CAS number | 129639-79-8 |
| ATC code | None |
| PubChem | CID 159326 |
| ChemSpider | 140124  |
| UNII | 11DI31LWXF |
| Chemical data | |
| Formula | C21H22N4OS |
| Mol. mass | 378.491 g/mol |
| SMILES | eMolecules & PubChem |
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Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.
Abasol is a topical cream formulation of abafungin by York Pharma.[1]
Mechanism of action
Like imidazole- and triazole-class antifungals, abafungin inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane.
In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.
Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[2]
References
- ^ York Pharma: Regulatory Update – Abasol
- ^ Ginter-Hanselmayer, Gabriele (March 2009), Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten, Österreichische Apothekerkammer, p. 103
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