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Skin absorption is a route by which substances can enter the body through the skin. Along with inhalation, ingestion and injection, dermal absorption is a route of exposure for toxic substances and route of administration for medication. Absorption of substances through the skin depends on a number of factors, the most important of which are concentration, duration of contact, *solubility of medication*, and physical condition of the skin and part of the body exposed. Certain substances called carriers can be used to greatly increase the amount of other substances that is able to penetrate the skin. Dimethyl sulfoxide (DMSO) is a carrier that is frequently used to transport medication through the skin. This allows treatment to be localized, unlike with ingestion. Alongside that, certain medications seem to be more effective (or are more efficient) using this route of administration, while it still remains clear that others are not.
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