Separation of individual prickle cells from their neighbors, as in keratosis follicularis.
Loss of cohesion between the epidermal cells, resulting in intraepidermal clefts, vesicles and bullae. Seen in inflammatory, viral and autoimmune skin diseases, particularly the pemphigus complex.
The loosening, separation, or disassociation of individual prickle cells within the epithelium from their neighbor, often seen in conditions such as pemphigus vulgaris and keratosis follicularis.