Acantholysis
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Acantholysis
Not to be confused with Acanthosis.
| Acantholysis | |
|---|---|
| Classification and external resources | |
 Foot-and-mouth disease. Acantholysis in a sample of a skin vesicle. Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa). |
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| ICD-10 | L11.9 (ILDS L11.900) |
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes[1], seen in diseases such as pemphigus vulgaris.[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.
This histological feature is also seen in herpes simplex infections (HSV 1 and 2).
See also
References
- ^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
- ^ Medical Dictionary Entry
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