Aceclofenac

aceclofenac

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An non-steroidal anti-inflammatory drug used for the treatment of pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (a type of arthritis affecting the spine). It is available as tablets on prescription only.

Side effects, precautions, and interactions with other drugs:
see non-steroidal anti-inflammatory drugs.

Proprietary preparation:
Preservex.

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Aceclofenac

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Aceclofenac

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Aceclofenac

Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	POM (UK)
Routes	oral, topical
Identifiers
CAS number	89796-99-6^N
ATC code	M01AB16 M02AA25
PubChem	CID 71771
ChemSpider	64809^Y
UNII	RPK779R03H^Y
KEGG	D01545^Y
ChEMBL	CHEMBL93645^Y
Chemical data
Formula	C₁₆H₁₃Cl₂N O₄
Mol. mass	354.18472 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)^Y Key:MNIPYSSQXLZQLJ-UHFFFAOYSA-N^Y
N (what is this?) (verify)

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID). Aceclofenac is marketed by Intas Pharmaceuticals, Ltd., under the brand name Hifenac in various forms. Aceclofenac is marketed by Kaptab Pharmaceuticals under the brand name Cincofen. In Pakistan it is marketed as Airtal. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily.

It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.

References

British National Formulary 55, March 2008; ISBN 978-0-85369-776-3 p. 537

Anti-inflammatory products (M01A)

Pyrazolidine/Butylpyrazolidines

Acetic acid derivatives
and related substances

Oxicams

Propionic acid derivatives

Fenamates

Coxibs

Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

v t e Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)

Salicylates	Aspirin (acetylsalicylic acid) Aloxiprin Benorylate Diflunisal Ethenzamide Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Sodium salicylate

Arylalkanoic acids	Diclofenac Aceclofenac Acemetacin Alclofenac Bromfenac Etodolac Indometacin Indometacin farnesil Nabumetone Oxametacin Proglumetacin Sulindac Tolmetin

2-Arylpropionic acids (profens)	Ibuprofen Alminoprofen Benoxaprofen Carprofen Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuproxam Indoprofen^† Ketoprofen Ketorolac Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tiaprofenic acid

N-Arylanthranilic acids (fenamic acids)	Mefenamic acid Flufenamic acid Meclofenamic acid Tolfenamic acid

Pyrazolidine derivatives	Phenylbutazone Ampyrone Azapropazone Clofezone Kebuzone Metamizole Mofebutazone Oxyphenbutazone Phenazone Sulfinpyrazone

Oxicams	Piroxicam Droxicam Lornoxicam Meloxicam Tenoxicam Ampiroxicam

COX -2 inhibitors	Celecoxib Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Parecoxib Rofecoxib^† Valdecoxib^†

Sulfonanilides	Nimesulide

Topically used products	Bendazac Diclofenac Etofenamate Felbinac Flurbiprofen Ibuprofen Indometacin Ketoprofen Naproxen Piroxicam Suprofen

COX-inhibiting nitric oxide donators	Naproxcinod

Others	Fluproquazone

Items listed in bold indicate initially developed compounds of specific groups. ^†Withdrawn drugs. ^‡Veterinary use medications.

Analgesics (N02A, N02B)

Opioids
See also: Opioids template

Opium & alkaloids thereof	Codeine^# Morphine^# Opium Laudanum Paregoric

Semi-synthetic opium derivatives	Acetyldihydrocodeine Benzylmorphine Buprenorphine Desomorphine Dihydrocodeine Dihydromorphine Ethylmorphine Diamorphine Hydrocodone Hydromorphinol Hydromorphone Nicocodeine Nicodicodeine Nicomorphine Oxycodone Oxymorphone

Synthetic opioids	Alphaprodine Anileridine Butorphanol Dextromoramide Dextropropoxyphene Dezocine Fentanyl Ketobemidone Levorphanol Methadone Meptazinol Nalbuphine Pentazocine Propoxyphene Propiram Pethidine Phenazocine Piminodine Piritramide Tapentadol Tilidine Tramadol

Pyrazolones

Cannabinoids

Anilides

Non-steroidal
anti-inflammatories
See also: NSAIDs template

Propionic acid class	Fenoprofen Flurbiprofen Ibuprofen^# Ketoprofen Naproxen Oxaprozin

Oxicam class	Meloxicam Piroxicam

Acetic acid class	Diclofenac Indometacin Ketorolac Nabumetone Sulindac Tolmetin

COX-2 inhibitors	Celecoxib Rofecoxib Valdecoxib Parecoxib Lumiracoxib

Anthranilic acid (fenamate) class	Meclofenamate Mefenamic acid

Salicylates	Aspirin (Acetylsalicylic acid)^# Benorylate Diflunisal Ethenzamide Magnesium salicylate Salicin Salicylamide Salsalate Trisalate Wintergreen (Methyl salicylate)

Atypical, adjuvant and potentiators,
metabolic agents and miscellaneous

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)

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