Aceclofenac

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An non-steroidal anti-inflammatory drug used for the treatment of pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (a type of arthritis affecting the spine). It is available as tablets on prescription only.

Side effects, precautions, and interactions with other drugs:
see non-steroidal anti-inflammatory drugs.

Proprietary preparation:
Preservex.

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Aceclofenac
Systematic (IUPAC) name
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status POM (UK)
Routes oral, topical
Identifiers
CAS number 89796-99-6 N
ATC code M01AB16 M02AA25
PubChem CID 71771
ChemSpider 64809 YesY
UNII RPK779R03H YesY
KEGG D01545 YesY
ChEMBL CHEMBL93645 YesY
Chemical data
Formula C16H13Cl2NO4 
Mol. mass 354.18472 g/mol
SMILES eMolecules & PubChem
 N (what is this?)  (verify)

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID). Aceclofenac is marketed by Intas Pharmaceuticals, Ltd., under the brand name Hifenac in various forms. Aceclofenac is marketed by Kaptab Pharmaceuticals under the brand name Cincofen. In Pakistan it is marketed as Airtal. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily.

It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.

Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.

References



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