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Acenocoumarol

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acenocoumarol

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An oral anticoagulant used for the prevention and treatment of deep-vein thrombosis and pulmonary embolism and for the prevention of embolism in people with atrial fibrillation (see arrhythmia) and in those who have received an artificial heart valve. It is available as tablets on prescription only.

Side effects, precautions, and interactions with other drugs:
see warfarin sodium.

Proprietary preparation:
Sinthrome.

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Wikipedia on Answers.com:

Acenocoumarol

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Acenocoumarol
Systematic (IUPAC) name
(RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. X
Legal status POM (UK)
Routes Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 8 to 11 hours
Identifiers
CAS number 152-72-7 YesY
ATC code B01AA07
PubChem CID 9052
DrugBank DB01418
ChemSpider 10443441 YesY
UNII I6WP63U32H YesY
KEGG D07064 YesY
ChEBI CHEBI:53766 YesY
ChEMBL CHEMBL397420 YesY
Chemical data
Formula C19H15NO6 
Mol. mass 353.326 g·mol-1
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

Dosage

Research in the RECAVA network has discovered that two acquired factors (age and body mass index) and three genetic polymorphisms (genes VKORC1, CYP2C9 and CYP4F2) are useful to establish the right dosage. Acenocoumarol is contraindicated during pregnancy.

External links

  • DDB 29202
  • Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673–6. doi:10.1097/00001721-200412000-00007. PMID 15613922. 
  • Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619–21. PMID 15724697. 
  • Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227–46. doi:10.2165/00003088-200544120-00003. PMID 16372822. 
  • Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183–7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310. 
Antiplatelet drugs
Other
Anticoagulants
Factor Xa inhibitors
(with some II inhibition)
Other
Thrombolytic drugs/
fibrinolytics
Non-medicinal
Types of coumarins
Aglycones
glycosides
Aesculin | Skimmin (7-O-β-D-glucopyranosylumbelliferone) | Scopolin
Furan derivatives
Monoterpene coumarin ether
Synthetic or drugs
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