Acenocoumarol

Acenocoumarol

Systematic (IUPAC) name
4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Identifiers
CAS number	152-72-7
ATC code	B01AA07
PubChem	9052
ChemSpider	10443441
Chemical data
Formula	C19H15NO6
Mol. mass	353.326 g·mol-1
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	8 to 11 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral
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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

External links

• DDB 29202
• Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673–6. doi:10.1097/00001721-200412000-00007. PMID 15613922. 
• Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619–21. PMID 15724697. 
• Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227–46. doi:10.2165/00003088-200544120-00003. PMID 16372822. 
• Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183–7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310. 

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