acetanilide

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Acetanilide
IUPAC name	N-phenylethanamide
Identifiers
CAS number	[103-84-4]
SMILES	O=C(C)Nc1ccccc1
Properties
Molecular formula	C6H5NH(COCH3)
Molar mass	135.17 g/mol
Density	1.219 g/cm³
Melting point	112–114°C (233–239 °F)
Boiling point	304 °C
Solubility in water	1 g/185 mL at 22°C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Acetanilide^[1] is an odourless solid chemical of leaf or flake-like appearance. It is also known as N-phenylacetamide, acetanil, or acetanilid, and was formerly known by the trade name Antifebrin.

Formation

Acetanilide can be produced by reacting acetic anhydride with either aniline or phenylammonium chloride

Properties

Acetanilide is slightly soluble in water. It has the ability to self-ignite if it reaches a temperature of 545 °C, but is otherwise stable under most conditions.^[2] Pure crystals are plate shaped, white in colour, and have a sugary aftertaste.

Applications

Acetanilide is used as an inhibitor in hydrogen peroxide and is used to stabilize cellulose ester varnishes. It has also found uses in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis. Acetanilide was used as a precursor in penicillin synthesis and other pharmaceuticals and its intermediates.

Acetanilide is a prodrug with analgesic and antipyretic (fever-reducing) properties; it is in the same class of drugs as acetaminophen (paracetamol). Under the name acetanilid it formerly figured in the formula of a number of patent medicines and over the counter drugs. In 1948, Julius Axelrod and Bernard Brodie discovered that acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately doing damage to the liver and kidneys. As such, acetanilide has largely been replaced by less toxic drugs, in particular acetaminophen, which is a metabolite of acetanilide and whose use Axelrod and Brodie suggested in the same study.

In the 19th century it was one of a large number of compounds used as experimental photographic developers.

Acetanilide is commonly used in organic chemistry labs for recrystallization experiments.

Notes

External links

• Acetanilide MSDS