Intermediate in ketogenesis and utilization of the ketones, beta-hydroxybutyrate and acetoacetate. Penultimate intermediate in the beta-oxidation of fatty acids.
Acetoacetyl-CoA
| Veterinary Dictionary: acetoacetyl CoA |
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| Wikipedia: Acetoacetyl-CoA |
| Acetoacetyl-CoA | |
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| Identifiers | |
| CAS number | 1420-36-6 |
| PubChem | 74 |
| MeSH | acetoacetyl+CoA |
| Properties | |
| Molecular formula | C25H40N7O18P3S |
| Molar mass | 851.609 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Acetoacetyl CoA is the precursor of HMG-CoA in the Mevalonate pathway, which is essential for cholesterol synthesis. It also takes a similar role in the ketone bodies synthesis pathway of the liver. In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a reactant.
It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. (During the metabolism of leucine, this last reaction is reversed.)
See also
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Learn More
 | coenzyme |
| Acetoacetyl-CoA hydrolase |
| Acetoacetate-CoA ligase |
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Copyrights:
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Acetoacetyl-CoA". Read more |
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