Acetohydroxamic acid

A hydroxamic acid that specifically inhibits urease; it retards alkalinization of the urine caused by urease-producing bacteria and may inhibit bacterial growth. Used in the prevention and dissolution of uroliths, but in dogs causes a dose-related, reversible hemolytic anemia and blood dyscrasia. Abbreviated AHA.

Acetohydroxamic acid
Systematic (IUPAC) name
ethanehydroxamic acid
Identifiers
CAS number	546-88-3
ATC code	G04BX03
PubChem	1990
DrugBank	APRD00774
ChemSpider	1913
Chemical data
Formula	C2H5NO2
Mol. mass	75.0666 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?
Y(what is this?)  (verify)

Acetohydroxamic acid (also known as AHA or Lithostat) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme (Fishbein and Carbone, 1965).

References

• W. Fishbein and P. Carbone J Biol Chem. 1965 Jun;240:2407-14

This pharmacology-related article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Urologicals (G04) Acidifiers Ammonium chloride · Calcium chloride Urinary antispasmodics (primarily antimuscarinics) Darifenacin · Emepronium · Fesoterodine · Flavoxate · Imidafenacin · Meladrazine · Oxybutynin · Propiverine · Solifenacin · Terodiline · Tolterodine · Trospium For erectile dysfunction Prostaglandins (E) Alprostadil PDE5 inhibitors Avanafil · Sildenafil citrate · Tadalafil · Udenafil · Vardenafil Alpha blockers Moxisylyte · Phentolamine · Yohimbine Dopamine D4 receptor agonists ABT-670 · ABT-724 Others Apomorphine · Papaverine Other urologicals Acetohydroxamic acid · Collagen · Dimethyl sulfoxide · Magnesium hydroxide · Pentosan polysulfate · Phenazopyridine · Phenyl salicylate · Succinimide For BPH 5α-reductase inhibitors Dutasteride · Finasteride Alpha blockers (α1) Alfuzosin · Doxazosin · Silodosin · Tamsulosin · Terazosin Herbals Pygeum africanum · Serenoa repens

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)