Acetyl-CoA C-acyltransferase

acetyl-CoA C-acyltransferase

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EC 2.3.1.16; systematic name: acyl-CoA:acetyl-CoA C-acyltransferase; other names: 3-ketoacyl-CoA thiolase; β-ketothiolase; an enzyme that catalyses the formation of acyl-CoA and acetyl-CoA from CoA and 3-oxoacyl-CoA. This is the concluding reaction of each cycle of the fatty acid oxidation pathway (beta oxidation). Different enzymes exist in the mitochondrion and peroxisome, both being included in the thiolase family.

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Acetyl-CoA C-acyltransferase

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acetyl-CoA C-acyltransferase

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The final step of beta oxidation is the cleavage of 3-ketoacyl CoA by the thiol group of another molecule of CoA. This reaction is catalyzed by Acetyl-CoA C-acyltransferase (or Β-ketothiolase). The thiol is inserted between C-2 and C-3, which yields an acetyl CoA molecule and an acyl CoA molecule, which is two carbons shorter.

Acetyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.

Mevalonate pathway

Ketogenesis

Examples

Human genes that encode acetyl-CoA C-acyltransferases include:

acetyl-CoA acyltransferase 1 (peroxisomal)
Identifiers
Symbol	ACAA1
Entrez	30
HUGO	82
OMIM	604054
RefSeq	NM_001607
UniProt	P09110
Other data
EC number	2.3.1.16
Locus	Chr. 3 p23-p22

acetyl-CoA acyltransferase 2 (mitochondrial)
Identifiers
Symbol	ACAA2
Entrez	10449
HUGO	83
OMIM	604770
RefSeq	NM_006111
UniProt	P42765
Other data
EC number	2.3.1.16
Locus	Chr. 18 q21

hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
Identifiers
Symbol	HADHB
Entrez	3032
HUGO	4803
OMIM	143450
RefSeq	NM_000183
UniProt	P55084
Other data
EC number	2.3.1.16
Locus	Chr. 2 p23

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MeSH Acetyl-CoA+C-Acyltransferase

This transferase article is a stub. You can help Wikipedia by expanding it.

v · d · eTransferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase - N-Acetylglutamate synthase - Choline acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Chloramphenicol acetyltransferase - N-acetyltransferase (Serotonin N-acetyl transferase, HGSNAT, ARD1A) - Histone acetyltransferase (P300/CBP, NAT2) palmitoyltransferases: Carnitine O-palmitoyltransferase (CPT1, CPT2) - Serine C-palmitoyltransferase (SPTLC1, SPTLC2) other: Acyltransferase like 2 - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase - 1-acylglycerol-3-phosphate O-acyltransferase - 2-acylglycerol-3-phosphate O-acyltransferase - ABHD5

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII)

2.3.3: converted into alkyl on transfer	Citrate synthase - ATP citrate lyase - HMG-CoA synthase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Metabolism: lipid metabolism / fatty acid metabolism · triglyceride and fatty acid enzymes

Synthesis

Malonyl-CoA synthesis	ATP citrate lyase · Acetyl-CoA carboxylase

Fatty acid synthesis/ Fatty acid synthase	Beta-ketoacyl-ACP synthase · Β-Ketoacyl ACP reductase · 3-Hydroxyacyl ACP dehydrase · Enoyl ACP reductase

Fatty acid desaturases	Stearoyl-CoA_desaturase-1

Triacyl glycerol	Glycerol-3-phosphate dehydrogenase · Thiokinase

Degradation

Acyl transport

Carnitine palmitoyltransferase I · Carnitine-acylcarnitine translocase · Carnitine palmitoyltransferase II

Beta oxidation

General	Acyl CoA dehydrogenase (ACADL, ACADM, ACADS, ACADVL, ACADSB) · Enoyl-CoA hydratase MTP: HADH · HADHA · HADHB Acetyl-CoA C-acyltransferase

Unsaturated	Enoyl CoA isomerase · 2,4 Dienoyl-CoA reductase

Odd chain	Propionyl-CoA carboxylase

Other	Hydroxyacyl-Coenzyme A dehydrogenase

To acetyl-CoA

Malonyl-CoA decarboxylase

Aldehydes

Long-chain-aldehyde dehydrogenase

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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