Acetyl-Coenzyme A acetyltransferase

Not to be confused with Acyl-CoA:cholesterol acyltransferase.

acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
Identifiers
Symbol	ACAT1
Alt. Symbols	ACAT
Entrez	38
HUGO	93
OMIM	607809
RefSeq	NM_000019
UniProt	P24752
Other data
EC number	2.3.1.9
Locus	Chr. 11 q22.3-23.1

acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
Identifiers
Symbol	ACAT2
Entrez	39
HUGO	94
OMIM	100678
RefSeq	NM_005891
UniProt	Q9BWD1
Other data
EC number	2.3.1.9
Locus	Chr. 6 q25.3-q26

Acetyl-Coenzyme A acetyltransferase (or thiolase) is an enzyme which converts two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway.

Mevalonate pathway

External links

• MeSH Acetyl-CoA+C-Acetyltransferase

This transferase article is a stub. You can help Wikipedia by expanding it.

v • d • e Transferases: acyltransferases (EC 2.3) 2.3.1: other than amino-acyl groups (mostly acetyltransferases) N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase (CPT1, CPT2) - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase (P300/CBP) - Serotonin N-acetyl transferase - Serine C-palmitoyltransferase (SPTLC1, SPTLC2) - HGSNAT 2.3.2: Aminoacyltransferases Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII) 2.3.3: converted into alkyl on transfer Citrate synthase - ATP citrate lyase - HMG-CoA synthase

v • d • e Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism Mevalonate pathway To HMG-CoA Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase Geranyl- Dimethylallyltranstransferase · Geranyl pyrophosphate To cholesterol To lanosterol Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase 7-Dehydrocholesterol path Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase Desmosterol path 24-dehydrocholesterol reductase To Bile acids Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase Steroidogenesis To pregnenolone Side-chain cleavage To corticosteroids aldosterone: 18-hydroxylase cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2) both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase To sex hormones To androgens 17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase To estrogens Aromatase Other/ungrouped Steroid sulfatase · Steroidogenic acute regulatory protein see also intermediates, disorders

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