the
l isomer,
N-acetyl-
l-glutamic acid, is a key intermediate in ornithine formation in bacteria and plants. It is converted to
N-acetyl-
l-glutamic
c-semialdehyde, from which
N-acetyl-
l-ornithine is formed in a transaminationreaction. It activates
carbamoyl-phosphate synthase, whichcatalyzes the synthesis of carbamoyl phosphate from ammonia and carbondioxide, the first committed step in the urea cycle. It is formed from acetyl-CoA and glutamate by the action of amino acid
N-acetyl transferase, EC 2.3.1.1.