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aconitate decarboxylase
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| Identifiers | ||||||
| EC number | 4.1.1.6 | |||||
| CAS number | 9025-01-8 | |||||
| IntEnz | IntEnz view | |||||
| BRENDA | BRENDA entry | |||||
| ExPASy | NiceZyme view | |||||
| KEGG | KEGG entry | |||||
| MetaCyc | metabolic pathway | |||||
| PRIAM | profile | |||||
| PDB | structures | |||||
| Gene Ontology | AmiGO / EGO | |||||
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In enzymology, an aconitate decarboxylase (EC 4.1.1.6) is an enzyme that catalyzes the chemical reaction
- cis-aconitate
itaconate + CO2
Hence, this enzyme has one substrate, cis-aconitate, and two products, itaconate and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is cis-aconitate carboxy-lyase (itaconate-forming). Other names in common use include cis-aconitic decarboxylase, CAD, cis-aconitate carboxy-lyase, and cis-aconitate carboxy-lyase. This enzyme participates in c5-branched dibasic acid metabolism.
References
- BENTLEY R, THIESSEN CP (1957). "Biosynthesis of itaconic acid in Aspergillus terreus. III. The properties and reaction mechanism of cis-aconitic acid decarboxylase". J. Biol. Chem. 226: 703–20. PMID 13438855.
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