Acropachy
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Acropachy
| Acropachy | |
|---|---|
| Classification and external resources | |
| OMIM | 119900 |
| DiseasesDB | 3054 |
Acropachy is a medical condition characterized by subperiosteal new bone formation, (aka Marie's Disease). This most commonly manifests as clubbing of the fingers and toes with soft tissue swelling. It is sometimes associated with Graves' disease but not with other causes of hyperthyroidism. There is no effective treatment for acropachy.
Thyroid acropachy is an extreme manifestation of autoimmune thyroid disease. It presents with digital clubbing, swelling of digits and toes, and periosteal reaction of extremity bones. It is often associated with ophthalmopathy[1] and thyroid dermopathy.[2]
Hereditary acropachy (also known as "isolated congenital nail clubbing") may be associated with HPGD.[3]
See also
References
- ^ Fatourechi V, Bartley GB, Eghbali-Fatourechi GZ, Powell CC, Ahmed DD, Garrity JA (December 2003). "Graves' dermopathy and acropachy are markers of severe Graves' ophthalmopathy". Thyroid 13 (12): 1141–4. doi:10.1089/10507250360731541. PMID 14751035.
- ^ Fatourechi V, Ahmed DD, Schwartz KM (December 2002). "Thyroid acropachy: report of 40 patients treated at a single institution in a 26-year period". J. Clin. Endocrinol. Metab. 87 (12): 5435–41. doi:10.1210/jc.2002-020746. PMID 12466333. http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=12466333.
- ^ Tariq M, Azeem Z, Ali G, Chishti MS, Ahmad W (January 2009). "Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC)". J. Med. Genet. 46 (1): 14–20. doi:10.1136/jmg.2008.061234. PMID 18805827. http://jmg.bmj.com/cgi/pmidlookup?view=long&pmid=18805827.
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