ACTC1

Actin, alpha, cardiac muscle 1
PDB rendering based on 1atn.
Available structures PDB 1atn, 1c0g, 1d4x, 1dej, 1eqy, 1esv, 1h1v, 1hlu, 1ijj, 1j6z, 1kxp, 1lcu, 1lot, 1m8q, 1ma9, 1mdu, 1mvw, 1nlv, 1nm1, 1nmd, 1nwk, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g, 1p8z, 1qz5, 1qz6, 1rdw, 1rfq, 1rgi, 1s22, 1sqk, 1t44, 1wua, 1y64, 1yxq, 2a3z, 2a40, 2a41, 2a42, 2a5x, 2asm, 2aso, 2asp, 2btf, 2d1k, 2ff3, 2ff6, 2fxu, 2gwj, 2gwk, 2hf3, 2hf4, 2hmp, 2oan, 2q1n, 2q31, 2q36
Identifiers
Symbols	ACTC1; ACTC; ASD5; CMD1R; CMH11; LVNC4
External IDs	OMIM: 102540 MGI: 87905 HomoloGene: 68446 GeneCards: ACTC1 Gene
Gene Ontology Molecular function • nucleotide binding • ATP binding • ATPase activity • myosin binding • myosin binding Cellular component • soluble fraction • cytoplasm • cytosol • cytoskeleton • actin filament • sarcomere • I band • actomyosin, actin part Biological process • ATP catabolic process • apoptosis • actin filament-based movement • muscle filament sliding • skeletal muscle thin filament assembly • actomyosin structure organization • actin-myosin filament sliding • response to drug • response to ethanol • cardiac myofibril assembly • cardiac muscle tissue morphogenesis • heart contraction • cardiac muscle contraction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	70	11464
Ensembl	ENSG00000159251	ENSMUSG00000068614
UniProt	P68032	Q3TG92
RefSeq (mRNA)	NM_005159	NM_009608.3
RefSeq (protein)	NP_005150	NP_033738.1
Location (UCSC)	Chr 15: 35.08 – 35.09 Mb	Chr 2: 113.87 – 113.88 Mb
PubMed search	[1]	[2]

Actin, alpha cardiac muscle 1 is a protein that in humans is encoded by the ACTC1 gene.^[1][2]

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is composed of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).^[2]

References

Further reading

v d e PDB gallery 1atn: Atomic structure of the actin:DNASE I complex   1c0g: CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H)   1d4x: Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution.   1dej: CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1   1eqy: COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1   1esv: COMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 1   1h1v: GELSOLIN G4-G6/ACTIN COMPLEX   1hlu: STRUCTURE OF BOVINE BETA-ACTIN-PROFILIN COMPLEX WITH ACTIN BOUND ATP PHOSPHATES SOLVENT ACCESSIBLE   1ijj: THE X-RAY CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RABBIT SKELETAL MUSCLE ACTIN AND LATRUNCULIN A AT 2.85 A RESOLUTION   1j6z: UNCOMPLEXED ACTIN   1kxp: CRYSTAL STRUCTURE OF HUMAN VITAMIN D-BINDING PROTEIN IN COMPLEX WITH SKELETAL ACTIN   1lcu: Polylysine Induces an Antiparallel Actin Dimer that Nucleates Filament Assembly: Crystal Structure at 3.5 A Resolution   1lot: CRYSTAL STRUCTURE OF THE COMPLEX OF ACTIN WITH VITAMIN D-BINDING PROTEIN   1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle   1ma9: Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin   1mdu: Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1)   1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1nlv: Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1   1nm1: Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A Resolution   1nmd: Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP   1nwk: CRYSTAL STRUCTURE OF MONOMERIC ACTIN IN THE ATP STATE   1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE   1p8z: Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156   1qz5: Structure of rabbit actin in complex with kabiramide C   1qz6: Structure of rabbit actin in complex with jaspisamide A   1rdw: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer   1rfq: Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer   1rgi: Crystal structure of gelsolin domains G1-G3 bound to actin   1s22: Absolute Stereochemistry of Ulapualide A   1sqk: CRYSTAL STRUCTURE OF CIBOULOT IN COMPLEX WITH SKELETAL ACTIN   1t44: Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation   1wua: The structure of Aplyronine A-actin complex   1y64: Bni1p Formin Homology 2 Domain complexed with ATP-actin   1yxq: Crystal structure of actin in complex with swinholide A   2a3z: Ternary complex of the WH2 domain of WASP with Actin-DNAse I   2a40: Ternary complex of the WH2 domain of WAVE with Actin-DNAse I   2a41: Ternary complex of the WH2 Domain of WIP with Actin-DNAse I   2a42: Actin-DNAse I Complex   2a5x: Crystal Structure of a Cross-linked Actin Dimer   2asm: Structure of Rabbit Actin In Complex With Reidispongiolide A   2aso: Structure of Rabbit Actin In Complex With Sphinxolide B   2asp: Structure of Rabbit Actin In Complex With Reidispongiolide C   2btf: THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN   2d1k: Ternary complex of the WH2 domain of mim with actin-dnase I   2ff3: Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin   2ff6: Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin   2fxu: X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.   2gwj: SpvB ADP-ribosylated actin: hexagonal crystal form   2gwk: SpvB ADP-ribosylated actin: orthorhombic crystal form   2hf3: Crystal structure of monomeric Actin in the ADP bound state   2hf4: Crystal structure of Monomeric Actin in its ATP-bound state   2hmp: Uncomplexed actin cleaved with protease ECP32   2oan: Structure of oxidized beta-actin   2q1n: Actin Dimer Cross-linked Between Residues 41 and 374   2q31: Actin Dimer Cross-linked Between Residues 41 and 374 and proteolytically cleaved by subtilisin between residues 47 and 48.   2q36: Actin Dimer Cross-linked between Residues 191 and 374 and complexed with Kabiramide C

External links

• GeneReviews/NIH/NCBI/UW entry on Familial Hypertrophic Cardiomyopathy Overview

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