Active placebo
Wikipedia on Answers.com:
Top
Active placebo
An active placebo is a placebo that mimics the common side effects of the drug under study.[1]
Nomenclature
According to a 1965 paper,[2] the term "fake placebo" (German: Kaschiertes Placebo) was suggested in a 1959 paper published in German.[3]
Example
Morphine and gabapentin are painkillers with the common side effects of sleepiness and dizziness. In a 2005 study assessing the effects of these painkillers on neuropathic pain, Lorazepam was chosen as an active placebo because it is not a painkiller but it does cause sleepiness and can cause dizziness.[4]
References
- ^ Jane Russell, quoted in about.com
- ^ Park LC, Covi U (April 1965). "Nonblind placebo trial: an exploration of neurotic patients' responses to placebo when its inert content is disclosed". Archives of General Psychiatry 12: 336–45. PMID 14258363. http://www.leecrandallparkmd.net/pdfs/placebo.pdf.
- ^ Haas H, Fink H, Haertfelder G (1959). "[The placebo problem]" (in German). Fortschr Arzneimittclforsch 1: 279–454. PMID 13710190.
- ^ Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RL (March 31, 2005). "Morphine, gabapentin, or their combination for neuropathic pain". N Engl J Med 352 (13): 1324–34. PMID 15800228. http://content.nejm.org/cgi/content/short/352/13/1324.
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
Wikipedia on Answers.com
This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Active placebo.
Read more