active site-directed irreversible inhibitor
Oxford Dictionary of Biochemistry:
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active site-directed irreversible inhibitor
a custom-made inhibitor of a given enzyme. Such inhibitors are typically trifunctional molecules containing: (1) a functional group able to bind to the enzyme's active site; (2) a nonpolar part that can interact with a nonpolar region on the enzyme, serving to align the inhibitor; and (3) an alkylating group capable of reacting with a susceptible group on the enzyme and irreversibly forming a covalent bond with it.
| active site, active one-carbon, active methyl | |
| active sulfate, active transport, active-enzyme centrifugation |
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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