ADAM protein (A Disintegrin And Metalloproteinase)[1] is a family of peptidase proteins[2]. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it[3]. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy[citation needed].
It is categorized under EC 3.4.24.46.
Types include:
References
- ^ Edwards DR, Handsley MM, Pennington CJ (October 2008). "The ADAM metalloproteinases". Mol. Aspects Med. 29 (5): 258–89. doi:. PMID 18762209. http://linkinghub.elsevier.com/retrieve/pii/S0098-2997(08)00055-1.
- ^ Wolfsberg TG, Straight PD, Gerena RL, et al. (1995). "ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain". Dev. Biol. 169 (1): 378–383. doi:. PMID 7750654.
- ^ Liu, P.C.; et al. (2006). "Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.". Cancer Biology and Therapy 6: 657–664. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16627989.
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