ADAM33
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ADAM33
| ADAM metallopeptidase domain 33 | |||||||||||||
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 PDB rendering based on 1r54. |
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| Identifiers | |||||||||||||
| Symbols | ADAM33; C20orf153; DJ964F7.1; DKFZp434K0521; FLJ35308; FLJ36751; MGC149823; MGC71889 | ||||||||||||
| External IDs | OMIM: 607114 MGI: 1341813 HomoloGene: 11881 GeneCards: ADAM33 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 80332 | 110751 | |||||||||||
| Ensembl | ENSG00000149451 | ENSMUSG00000027318 | |||||||||||
| UniProt | Q9BZ11 | Q6TYY9 | |||||||||||
| RefSeq (mRNA) | NM_025220.2 | NM_033615 | |||||||||||
| RefSeq (protein) | NP_079496.1 | NP_291093 | |||||||||||
| Location (UCSC) | Chr 20: 3.65 – 3.66 Mb |
Chr 2: 130.88 – 130.89 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.[1][2]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]
References
- ^ Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (Jan 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene 282 (1–2): 227–36. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.
- ^ a b "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80332.
Further reading
- Holgate ST, Davies DE, Rorke S et al. (2005). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical reviews in allergy & immunology 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID 15347848.
- Holloway JW, Davies DE, Powell R et al. (2007). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert reviews in molecular medicine 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895.
- Holgate ST, Yang Y, Haitchi HM et al. (2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society 3 (5): 440–3. doi:10.1513/pats.200603-026AW. PMID 16799089.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Van Eerdewegh P, Little RD, Dupuis J et al. (2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature 418 (6896): 426–30. doi:10.1038/nature00878. PMID 12110844.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Garlisi CG, Zou J, Devito KE et al. (2003). "Human ADAM33: protein maturation and localization". Biochem. Biophys. Res. Commun. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID 12535637.
- Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". J. Hum. Genet. 48 (5): 278–81. doi:10.1007/s10038-003-0019-1. PMID 12768445.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Howard TD, Postma DS, Jongepier H et al. (2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". J. Allergy Clin. Immunol. 112 (4): 717–22. doi:10.1016/S0091. PMID 14564349.
- Orth P, Reichert P, Wang W et al. (2004). "Crystal structure of the catalytic domain of human ADAM33". J. Mol. Biol. 335 (1): 129–37. doi:10.1016/j.jmb.2003.10.037. PMID 14659745.
- Zou J, Zhu F, Liu J et al. (2004). "Catalytic activity of human ADAM33". J. Biol. Chem. 279 (11): 9818–30. doi:10.1074/jbc.M309696200. PMID 14676211.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Powell RM, Wicks J, Holloway JW et al. (2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". Am. J. Respir. Cell Mol. Biol. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294.
- Haitchi HM, Powell RM, Shaw TJ et al. (2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". Am. J. Respir. Crit. Care Med. 171 (9): 958–65. doi:10.1164/rccm.200409-1251OC. PMID 15709049.
- Zou J, Zhang R, Zhu F et al. (2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry 44 (11): 4247–56. doi:10.1021/bi0476230. PMID 15766253.
- Simpson A, Maniatis N, Jury F et al. (2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". Am. J. Respir. Crit. Care Med. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180.
External links
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