| Adamantinoma | |
|---|---|
| Classification and external resources | |
| ICD-O: | 9310/0 |
| DiseasesDB | 31676 |
| eMedicine | radio/11 |
| MeSH | D050398 |
Adamantinoma (from the Greek word adamantinos, meaning "very hard"[1]) is a rare bone cancer, making up less than 1% of all bone cancers.
It includes epithelial components.[2]
The condition was first described by Fischer in 1913.[3][4].
Contents |
Presentation
It predominantly arises in bone in a subcutaneous location (most are in the tibia).[5] Most commonly, patients are in their second or third decade, but it can occur over a wide age range.
Histologically, islands of epithelial cells are found in a fibrous stroma.
Treatment
Treatment consists of wide resection or amputation. Metastases are rare at presentation but may occur in up to 30% of patients during the disease course. Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.
Prior name for ameloblastoma
The typically benign odontogenic tumor known as ameloblastoma was first recognized in 1827 by Cusack but did not yet have any designation.[6] In 1885, this kind of odontogenic neoplasm was designated as an adamantinoma by Malassez[7] and was finally renamed to the modern name ameloblastoma in 1930 by Ivey and Churchill.[8][9] It should be noted that some authors still confusingly misuse the term adamantinoma to describe ameloblastomas, however they differ in histology and frequency of malignancy.
References
- ^ Brazis PW, Miller NR, Lee AG, Holliday MJ (1995). "Neuro-ophthalmologic Aspects of Ameloblastoma". Skull Base Surg 5 (4): 233–44. PMID 17170964.
- ^ Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S (May 2006). "A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature". Tohoku J. Exp. Med. 209 (1): 53–9. PMID 16636523. http://joi.jlc.jst.go.jp/JST.JSTAGE/tjem/209.53?from=PubMed.
- ^ "Adamantinoma: Overview - eMedicine". http://emedicine.medscape.com/article/385977-overview. Retrieved 2009-01-04.
- ^ Fischer B. Uber ein primares Adamantinom der Tibia. 12. Frankfurt: Zeitschr. f. Path.; 1913:422-441.
- ^ Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y (2008). "Adamantinoma: A clinicopathological review and update". Diagn Pathol 3: 8. doi:. PMID 18279517. PMC 2276480. http://www.diagnosticpathology.org/content/3//8.
- ^ J.W. Cusack (1827). "Report of the amputations of the lower jaw". Dublin Hosp Rec 4: 1–38.
- ^ L. Malassez (1885). "Sur Le role des debris epitheliaux papdentaires". Arch Physiol Norm Pathol 5: 309–340 6:379–449.
- ^ R.H. Ivey, H.R. Churchill, (1930). "The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin,". Am Assoc Dent Sch Trans 7: 240–245.
- ^ "Giant ameloblastoma of jaw successfully treated by radiotherapy". Oral Oncology Extra 42 (1): 22–25. Jan 2006. doi:.
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