Adaptin
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a major coat protein of clathrin-coated vesicles. It functions as a component of the adaptor complexes that link clathrin to the receptors being taken into the cell in the coated vesicles, recognizing a motif of four amino acids (FRxY) in the cytoplasmic domain of the receptor.
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Adaptin
Adaptins are proteins that mediate the formation of vesicles by clathrin-coated pits, through interaction with membrane-bound receptors. There are several types of adaptin, each related to a different group of such receptors.
Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.
Adaptins cluster to form the AP2 complex.
The Adaptin complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma):
- complex 1
- complex 2
- complex 3
- complex 4
References
- Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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