Adaptor Hypothesis

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the proposal that polynucleotide adaptor molecules exist that can recognize specific amino acids and also the regions of the RNA templates that specify the placement of amino acids in a newly forming polypeptide. See Chronology, 1958, Crick; transfer RNA.

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the hypothesis, first postulated by the British molecular biologist Francis Crick (1916 —  ), that during protein biosynthesis each amino-acid residue is carried to the RNA template by its appropriate small adaptor RNA molecule, and that the adaptor is the part that fits on to the messenger RNA. The hypothesis was subsequently confirmed by the discovery of transfer RNA.

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Paul Berg (American molecular biologist)
Mahlon Bush Hoagland (American biochemist)
DNA