ADCY1: Information from Answers.com

Adenylate cyclase 1 (brain)

Identifiers

External IDs

OMIM: 103072 MGI: 99677 HomoloGene: 41419

Gene ontology
Molecular function	• magnesium ion binding • calmodulin binding • calcium- and calmodulin-responsive adenylate cyclase activity
Cellular component	• membrane • integral to membrane
Biological process	• cAMP biosynthetic process • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq

NM_021116 (mRNA)

NM_009622 (mRNA)

NP_066939 (protein)

NP_033752 (protein)

Location

Chr 7:
45.58 - 45.73 Mb

Chr 11:
6.96 - 7.08 Mb

PubMed search

[1]

[2]

Adenylate cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.^[1]^[2]

This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.^[2]

References

^ Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR (Jul 1993). "Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase". Genomics 16 (2): 473-8. doi:10.1006/geno.1993.1213. PMID 8314585.
^ ^a ^b "Entrez Gene: ADCY1 adenylate cyclase 1 (brain)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=107.

Osawa S, Dhanasekaran N, Woon CW, Johnson GL (1990). "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions.". Cell 63 (4): 697–706. PMID 2121366.
Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes.". Hum. Genet. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689.
Whisnant RE, Gilman AG, Dessauer CW (1996). "Interaction of the two cytosolic domains of mammalian adenylyl cyclase.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6621–5. doi:10.1073/pnas.93.13.6621. PMID 8692867.
Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMID 11884542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.". J. Recept. Signal Transduct. Res. 22 (1-4): 79–110. PMID 12503609.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Tucholski J, Johnson GV (2003). "Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation.". J. Biol. Chem. 278 (29): 26838–43. doi:10.1074/jbc.M303683200. PMID 12743114.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang H, Ferguson GD, Pineda VV, et al. (2004). "Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.". Nat. Neurosci. 7 (6): 635–42. doi:10.1038/nn1248. PMID 15133516.
Vortherms TA, Nguyen CH, Berlot CH, Watts VJ (2005). "Using molecular tools to dissect the role of Galphas in sensitization of AC1.". Mol. Pharmacol. 66 (6): 1617–24. doi:10.1124/mol.104.000166. PMID 15361543.
Weber B, Schaper C, Scholz J, et al. (2006). "Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase.". Cell. Signal. 18 (10): 1748–57. doi:10.1016/j.cellsig.2006.01.017. PMID 16531006.
Nlend MC, Schmid A, Sutto Z, et al. (2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia.". FEBS Lett. 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMID 17586501.

This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.

Phosphorus-oxygen lyases (EC 4.6)

4.6.1

Adenylate cyclase	intracellular: ADCY1 · ADCY2 · ADCY3 · ADCY4 · ADCY5 · ADCY6 · ADCY7 · ADCY8 · ADCY9 · ADCY10 Extracellular adenylate cyclase

Guanylate cyclase	soluble: GUCY1A2 · GUCY1A3 · GUCY1B2 · GUCY1B3 membrane-bound: Guanylyl cyclase c/GUCY2C · GUCY2D

Other	Cytidylate cyclase · 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase · Phosphatidylinositol diacylglycerol-lyase · Glycosylphosphatidylinositol diacylglycerol-lyase · FAD-AMP lyase (cyclizing)

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ADCY1

References

Further reading