Adducin

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a ubiquitously expressed protein found in the membranes of animal cells. Mammalian adducin is a heterodimeric protein whose subunits share sequence similarities and contain protease-resistant N-terminal and protease-sensitive C-terminal domains. Adducin has a high affinity for Ca2+/calmodulin and is a substrate for protein kinases. In vitro it causes actin filaments to form bundles and promotes spectrin-actin associations in regions where cells contact one another. In Drosophila, a homolog of mammalian adducin is encoded by the hts gene. , fusome, hu-li tai shao (hts), heterodimer, protein kinase, spectrosome.


a membrane skeleton protein (heterodimer) that interacts with a junctional complex that links spectrin assemblies. The complex in the red blood cell consists of tropomyosin and actin with band 4.1 (see band). Adducin probably binds to band 4.1.

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