a ubiquitously expressed protein found in the membranes of animal cells. Mammalian adducin is a heterodimeric protein whose subunits share sequence similarities and contain protease-resistant N-terminal and protease-sensitive C-terminal domains. Adducin has a high affinity for Ca
2+/calmodulin and is a substrate for protein kinases.
In vitro it causes actin filaments to form bundles and promotes spectrin-actin associations in regions where cells contact one another. In Drosophila, a homolog of mammalian adducin is encoded by the hts gene. , fusome, hu-li tai shao (hts), heterodimer, protein kinase, spectrosome.