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Drug Info:

Adefovir

Brand names: Hepsera®

Chemical formula:



Adefovir tablets

What are Adefovir tablets?

ADEFOVIR (Hepsera™) is used to treat infections due to the hepatitis B virus. Adefovir can slow the liver damage caused by hepatitis B. It will not cure or prevent hepatitis B infection. Generic adefovir tablets are not available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• human immunodeficiency virus (HIV) infection or AIDS
• kidney disease
• other liver disease
• an unusual reaction to adefovir, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should this medicine be used?

Take adefovir tablets by mouth. Follow the directions on the prescription label. Swallow tablets with a drink of water. If adefovir upsets your stomach, you can take it with food. Try to take your dose at the same time each day. Do not take your medicine more often than directed. Do not stop taking this medicine except on your prescriber's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, but then remember it during that same day, take it as soon as you can. Then take your next dose at the regularly scheduled time the following day. Do not take 2 doses at once to make up for a missing dose. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you are still unsure about what to do if you miss a dose, check with your prescriber.

What drug(s) may interact with Adefovir?

• certain antibiotics given by injection
• cyclosporine
• ibuprofen or other antiinflammatory drugs (NSAIDs)
• medicines for HIV infection or AIDS
• metformin
• tacrolimus

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking Adefovir?

You must visit your prescriber or health care professional for regular checks on your progress during and after treatment with adefovir. You will need regular blood tests to check for liver function and hepatitis B virus levels.

Discuss any new symptoms with your prescriber or health care professional. Tell your prescriber or health care professional at once if you have nausea and vomiting accompanied by severe stomach pain. Some people have worsening of hepatitis after stopping adefovir therapy. Do not stop taking adefovir unless your prescriber instructs you to.

Adefovir will not cure hepatitis B infection and you can still get other illnesses or complications associated with your disease. Taking adefovir does not reduce the risk of passing hepatitis B infection to others through sexual or blood contact. Do not have sexual contact without protection; talk to your health care professional about practicing 'safe sex', such as using condoms. Be careful about cuts, abrasions and other possible sources of blood contact. Do not share razors, toothbrushes or other personal items that might have contact with blood. Never share a needle or syringe with anyone.

Your prescriber may talk to you about being tested for the HIV virus prior to starting or during treatment with adefovir for hepatitis B. The use of adefovir can cause resistance to certain HIV medicines.

What side effects may I notice from receiving Adefovir?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• breathing difficulties or shortness of breath
• dark yellow or brown urine
• dizziness
• fever, chills, or frequent sore throat
• not passing urine as often as usual
• passing out or fainting
• severe diarrhea
• skin rash
• slow or irregular heart beat
• unusual muscle pain
• unusual weakness, fatigue, or discomfort
• unusual stomach pain or discomfort
• vomiting
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• headache
• heartburn or indigestion
• itching
• loss of appetite
• nausea
• stomach gas or fullness

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store between 15—30 degrees C (59—86 degrees F). Keep the container tightly closed. Throw away any unused medicine after the expiration date.

Last updated: 1/13/2004 1:57:00 PM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

 
 
Wikipedia: adefovir
Adefovir.png
Adefovir
Systematic (IUPAC) name
2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
Identifiers
CAS number 142340-99-6
ATC code J05AF08
PubChem 60172
DrugBank APRD00781
Chemical data
Formula C8H12N5O4P 
Mol. mass 273.186 g/mol
Pharmacokinetic data
Bioavailability 59%
Metabolism  ?
Half life 7.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

Prescription only

Routes  ?
Adefovir dipivoxil
Adefovir dipivoxil

Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon® and Hepsera®, is an orally-administered nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is a failed treatment for HIV.

History

Adefovir was invented in the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic by Antonín Holý, and the drug was developed by Gilead Sciences for HIV with the brand name Preveon. However, in November 1999, an expert panel advised the U.S. Food and Drug Administration (FDA) not to approve the drug due to concerns about the severity and frequency of kidney toxicity when dosed at 60 or 120 mg. The FDA followed that advice, refusing to approve adefovir as a treatment for HIV.

Gilead Sciences discontinued its development for HIV treatment in December 1999 but continued to develop the drug for hepatitis B (HBV), where it is effective with a much lower dose of 10 mg. FDA approval for use in the treatment of hepatitis B was granted on September 20, 2002, and adefovir is sold for this indication under the brand name Hepsera.

Adefovir became an approved treatment for HBV in the United States in September 2002 and in the European Union in March 2003.

Mechanism of action

Adefovir works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

It is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease.

The main benefit of adefovir over lamivudine (the first NRTI approved for the treatment of hepatitis B) is that it takes a much longer period of time before the virus develops resistance to it.

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Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Adefovir" Read more

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