Adiposogenital dystrophy

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Adiposogenital dystrophy
Classification and external resources
ICD-10	E 23.6
ICD-9	253.8
DiseasesDB	29318

Adiposogenital dystrophy is a condition which may be caused by secondary hypogonadism originating from decreased levels in GnRH. Low levels of GnRH has been associated with defects of the feeding centers of the hypothalamus, leading to an increase consumption of food and thus caloric intake.

Contents

1 Presentation
2 Synonyms
3 See also
4 References

Presentation

It is characterized by:

Feminine obesity
Growth retardation and retarded sexual development, atrophy or hypoplasia of the gonads, and altered secondary sex characteristics,
headaches
Problems with vision
polyuria, polydipsia.

It is usually associated with tumours of the hypothalamus, causing increased appetite and depressed secretion of gonadotropin. It seems to affect males mostly.

Many overweight children may appear to have the disorder because of the concurrence of obesity and retarded sexual development; these children have no endocrine disturbances, however, and they mature normally after delayed puberty.

Synonyms

It has several other names:^[1]

Babinski-Fröhlich syndrome^[2] (named after Joseph Babinski^[3] and Alfred Fröhlich,^[4] but probably first described by Morgagni).^{[citation needed]} (It was given its name by Harvey Cushing.)^[5]commonly associated with slipped capital femoral epiphysis
Froelich's syndrome
Frölich's Syndrome
Hypothalamic Infantilism-Obesity
Launois-Cleret Syndrome
Sexual Infantilism

References

^ National Organisation for Rare Disorders - Froelich's syndrome
^ synd/1792 at Who Named It? - Babinski-Fröchlich syndrome
^ J. F. Babinski. Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux. Revue neurologique, Paris, 1900, 8: 531-535.
^ A. Fröhlich. Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wiener klinische Rundschau, 1901, 15: 833-836; 906-908.
^ Zárate A, Saucedo R (2007). "[The adiposogenital distrophy or Frohlich syndrome and the beginning of the concept of neuroendocrinology]" (in Spanish; Castilian). Gac Med Mex 143 (4): 349–50. PMID 17969845.

Endocrine pathology: endocrine diseases (E00–E35, 240–259)

Pancreas/
glucose
metabolism

Hypofunction	Diabetes mellitus types: (type 1, type 2, MODY 1 2 3 4 5 6) · complications (coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy, cardiomyopathy) insulin receptor (Rabson–Mendenhall syndrome) · Insulin resistance

Hyperfunction	Hypoglycemia · beta cell (Hyperinsulinism) · G cell (Zollinger–Ellison syndrome)

Hypothalamic/
pituitary axes

Hypothalamus

gonadotropin (Kallmann syndrome, Adiposogenital dystrophy) · CRH (Tertiary adrenal insufficiency) · vasopressin (Neurogenic diabetes insipidus) · general (Hypothalamic hamartoma)

Pituitary

Hyperpituitarism	anterior (Acromegaly, Hyperprolactinaemia, Pituitary ACTH hypersecretion) · posterior (SIADH) · general (Nelson's syndrome)

Hypopituitarism	anterior (Kallmann syndrome, Growth hormone deficiency, ACTH deficiency/Secondary adrenal insufficiency) · posterior (Neurogenic diabetes insipidus) · general (Empty sella syndrome, Pituitary apoplexy, Sheehan's syndrome, Lymphocytic hypophysitis)

Thyroid

Hypothyroidism	Iodine deficiency · Cretinism (Congenital hypothyroidism) · Myxedema · Euthyroid sick syndrome

Hyperthyroidism	Hyperthyroxinemia (Thyroid hormone resistance, Familial dysalbuminemic hyperthyroxinemia) · Hashitoxicosis · Thyrotoxicosis factitia · Graves' disease

Thyroiditis	Acute infectious · Subacute (De Quervain's, Subacute lymphocytic) · Autoimmune/chronic (Hashimoto's, Postpartum, Riedel's)

Goitre	Endemic goitre · Toxic nodular goitre · Toxic multinodular goiter Thyroid nodule

Parathyroid

Hypoparathyroidism	Pseudohypoparathyroidism

Hyperparathyroidism	Primary · Secondary · Tertiary · Osteitis fibrosa cystica

Adrenal

Hyperfunction	aldosterone: Hyperaldosteronism/Primary aldosteronism (Conn syndrome, Bartter syndrome, Glucocorticoid remediable aldosteronism) · AME · Liddle's syndrome · 17α CAH cortisol: Cushing's syndrome (Pseudo-Cushing's syndrome) sex hormones: 21α CAH · 11β CAH

Hypofunction/ Adrenal insufficiency (Addison's, WF)	aldosterone: Hypoaldosteronism (21α CAH, 11β CAH) cortisol: CAH (Lipoid, 3β, 11β, 17α, 21α) sex hormones: 17α CAH