abbr.: AGE; a product of the nonenzymatic glycation by glucose, fructose, or glyceraldehyde-3-phosphate, of extra- or intracellular proteins. High-affinity AGE receptors are present on monocytes, macrophages, liver, renal glomeruli and endothelial cells. AGEs contribute to age-dependent modification and crosslinking of tissue proteins, as in cataract formation, nephropathy, and vascular complications of diabetes mellitus.