advanced glycation end product

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Oxford Dictionary of Biochemistry:

advanced glycation end product

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abbr.: AGE; a product of the nonenzymatic glycation by glucose, fructose, or glyceraldehyde-3-phosphate, of extra- or intracellular proteins. High-affinity AGE receptors are present on monocytes, macrophages, liver, renal glomeruli and endothelial cells. AGEs contribute to age-dependent modification and crosslinking of tissue proteins, as in cataract formation, nephropathy, and vascular complications of diabetes mellitus.

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