Afamin
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Afamin
| Afamin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | AFM; ALB2; ALBA; ALF | ||||||||||||
| External IDs | OMIM: 104145 MGI: 2429409 HomoloGene: 881 GeneCards: AFM Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 173 | 280662 | |||||||||||
| Ensembl | ENSG00000079557 | ENSMUSG00000029369 | |||||||||||
| UniProt | P43652 | O89020 | |||||||||||
| RefSeq (mRNA) | NM_001133.2 | NM_145146.2 | |||||||||||
| RefSeq (protein) | NP_001124.1 | NP_660128.2 | |||||||||||
| Location (UCSC) | Chr 4: 74.35 – 74.37 Mb |
Chr 5: 90.95 – 90.98 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Afamin is a protein that in humans is encoded by the AFM gene.[1][2]
This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.[2]
References
- ^ Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM (Aug 1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family". J Biol Chem 269 (27): 18149–54. PMID 7517938.
- ^ a b "Entrez Gene: AFM afamin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=173.
Further reading
- Noppe M, Lowenthal A, Karcher D, Gheuens J (1979). "A two-site immunoradiometric assay for the determination of alpha-albumin.". J. Immunol. Methods 27 (1): 75–81. doi:10.1016/0022-1759(79)90240-0. PMID 37276.
- Hansson E, Rönnbäck L, Lowenthal A, Noppe M (1985). "Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis.". Brain Res. 353 (2): 175–85. PMID 4041902.
- Lowenthal A, Flament-Durand J, Karcher D, et al. (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland.". J. Neurochem. 38 (3): 863–5. doi:10.1111/j.1471-4159.1982.tb08714.x. PMID 7035619.
- Allard D, Gilbert S, Lamontagne A, et al. (1995). "Identification of rat alpha-albumin and cDNA cloning of its human ortholog.". Gene 153 (2): 287–8. doi:10.1016/0378-1119(94)00745-E. PMID 7875606.
- Nishio H, Heiskanen M, Palotie A, et al. (1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription.". J. Mol. Biol. 259 (1): 113–9. doi:10.1006/jmbi.1996.0306. PMID 8648639.
- Nishio H, Dugaiczyk A (1996). "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7557–61. doi:10.1073/pnas.93.15.7557. PMID 8755513.
- Song YH, Naumova AK, Liebhaber SA, Cooke NE (1999). "Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster.". Genome Res. 9 (6): 581–7. doi:10.1101/gr.9.6.581. PMC 310762. PMID 10400926. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310762.
- Khan MA, Kumar Y, Tayyab S (2003). "Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin.". Int. J. Biol. Macromol. 30 (3-4): 171–8. doi:10.1016/S0141-8130(02)00017-X. PMID 12063119.
- Voegele AF, Jerković L, Wellenzohn B, et al. (2003). "Characterization of the vitamin E-binding properties of human plasma afamin.". Biochemistry 41 (49): 14532–8. doi:10.1021/bi026513v. PMID 12463752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.". Proteomics 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Jerkovic L, Voegele AF, Chwatal S, et al. (2005). "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.". J. Proteome Res. 4 (3): 889–99. doi:10.1021/pr0500105. PMID 15952736.
- Hu Y, Malone JP, Fagan AM, et al. (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.". Mol. Cell Proteomics 4 (12): 2000–9. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.
- Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.
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