Afloqualone
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Afloqualone
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| Systematic (IUPAC) name | |
| 6-amino- 2-(fluoromethyl)- 3-(2-methylphenyl) quinazolin- 4-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 56287-74-2 |
| ATC code | None |
| PubChem | CID 2040 |
| ChemSpider | 1960  |
| UNII | CO4U2C8ORZ |
| KEGG | D01638 |
| Chemical data | |
| Formula | C16H14FN3O |
| Mol. mass | 283.3 |
| SMILES | eMolecules & PubChem |
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Afloqualone (Arofuto) is an analogue of methaqualone developed in the 1980s in Japan. It has sedative and muscle relaxant effects,[1] and has had some clinical use, although it causes photosensitization as a side effect which can cause skin problems such as dermatitis.[2]
See also
- Methaqualone
- Diproqualone
- Etaqualone
- Methylmethaqualone
- Mecloqualone
- Mebroqualone
- Cloroqualone
- Nitromethaqualone
References
- ^ Ochiai T, Ishida R. Pharmacological studies on 6-amino- 2-fluoromethyl- 3-(O-tolyl)- 4(3H)- quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Japanese Journal of Pharmacology. 1982 Jun;32(3):427-38.
- ^ Ishikawa T, Kamide R, Niimura M. Photoleukomelanodermatitis (Kobori) induced by afloqualone. Journal of Dermatology. 1994 Jun;21(6):430-3.
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