agalsidase

Genetically engineered forms of the enzyme α-galactosidase A, agalsidase alfa and agalsidase beta, used in the treatment of Fabry's disease, an inherited condition due to a lack of this enzyme that has effects on the skin, heart, kidneys, and nervous system. Both drugs are available in forms for intravenous injection on prescription only.

Side effects:
include headache, 'pins and needles', dizziness, sleepiness, a burning sensation, fainting, increased production of tears, tinnitus, vertigo, palpitations, and a fast or slow heart rate.

Precautions:
agalsidase alfa and beta carry a risk of allergic reactions. They are not recommended for use in pregnant or breastfeeding women.

Proprietary preparations:
Fabrazyme (agalsidase beta); Replagal (agalsidase alfa).

Previous:	aerosol, adrenoceptors, adrenaline
Next:	agomelatine, agonist, alclometasone dipropionate