Agathocles was the name of several ancient Greeks:
- Agathocles, a sophist, teacher of Damon
- Agathocles (writers), was the name of a number of ancient writers, including an ancient historian referred to by Pliny and Cicero
- Agathocles, the tyrant of Syracuse
- Agathocles (son of Lysimachus), the son and heir of Lysimachus
- Agathocles of Bactria, an Indo-Greek king who ruled about 185 BC
- Agathocles of Egypt, guardian of Ptolemy V Epiphanes
- Agathoclea, mistress of Ptolemy IV Philopator and sister of the above
It is also the name of:
- Agathocles (band), a grindcore band
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