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Aging: Causes and symptoms

 
Medical Encyclopedia: Aging: Causes and symptoms

There are several theories as to why the aging body loses functioning. It may be that several factors work together or that one particular factor is at work more than others in a given individual.

  • Programmed senescence, or aging clock, theory. The aging of the cells of each individual is programmed into the genes, and there is a preset number of possible rejuvenations in the life of a given cell. When cells die at a rate faster than they are replaced, organs do not function properly, and they are soon unable to maintain the functions necessary for life.
  • Genetic theory. Human cells maintain their own seed of destruction at the level of the chromosomes.
  • Connective tissue, or cross-linking theory. Changes in the make-up of the connective tissue alter the stability of body structures, causing a loss of elasticity and functioning, and leading to symptoms of aging.
  • Free-radical theory. The most commonly held theory of aging, it is based on the fact that ongoing chemical reactions of the cells produce free radicals. In the presence of oxygen, these free radicals cause the cells of the body to break down. As time goes on, more cells die or lose the ability to function, and the body soon ceases to function as a whole.
  • Immunological theory. There are changes in the immune system as it begins to wear out, and the body is more prone to infections and tissue damage, which may finally cause death. Also, as the system breaks down, the body is more apt to have autoimmune reactions, in which the body's own cells are mistaken for foreign material and are destroyed or damaged by the immune system.

— Patience Paradox



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