AGR2
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| Anterior gradient homolog 2 (Xenopus laevis) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | AGR2; AG2; GOB-4; HAG-2; PDIA17; XAG-2 | ||||||||||||
| External IDs | OMIM: 606358 MGI: 1344405 HomoloGene: 4674 GeneCards: AGR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10551 | 23795 | |||||||||||
| Ensembl | ENSG00000106541 | ENSMUSG00000020581 | |||||||||||
| UniProt | O95994 | O88312 | |||||||||||
| RefSeq (mRNA) | NM_006408 | NM_011783.2 | |||||||||||
| RefSeq (protein) | NP_006399 | NP_035913.1 | |||||||||||
| Location (UCSC) | Chr 7: 16.83 – 16.87 Mb |
Chr 12: 36.72 – 36.73 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Anterior gradient homolog 2 (AGR2) is a human protein originally discovered in Xenopus laevis, encoded for by the gene of the same name.[1] In Xenopus AGR2 plays a role in cement gland differentiation[2], however in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response and AGR2 levels are elevated in the preneoplastic tissue Barrett's oesophagus.[3]
References
- ^ "Entrez Gene: AGR2 anterior gradient homolog 2 (Xenopus laevis)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10551.
- ^ Aberger, F., Weidinger, G., Grunz, H., Richter, K. (1998). "Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2". Mech. Dev. 72 (1–2): 115–130. doi:10.1016/S0925-4773(98)00021-5. PMID 9533957.
- ^ Elizabeth Pohler, Ashley L. Craig, James Cotton, Laura Lawrie, John F. Dillon, Pete Ross, Neil Kernohan and Ted R. Hupp (2004). "The Barrett’s Antigen Anterior Gradient-2 Silences the p53 Transcriptional Response to DNA Damage". Molecular and Cellular Proteomics 3 (6): 534–547. doi:10.1074/mcp.M300089-MCP200. PMID 14967811.
Further reading
- Thompson DA, Weigel RJ (1998). "hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines". Biochem. Biophys. Res. Commun. 251 (1): 111–6. doi:10.1006/bbrc.1998.9440. PMID 9790916.
- Petek E, Windpassinger C, Egger H, et al. (2000). "Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation". Cytogenet. Cell Genet. 89 (3–4): 141–2. doi:10.1159/000015594. PMID 10965104.
- Fletcher GC, Patel S, Tyson K, et al. (2003). "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan". Br. J. Cancer 88 (4): 579–85. doi:10.1038/sj.bjc.6600740. PMC 2377166. PMID 12592373. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2377166.
- Zhang JS, Gong A, Cheville JC, et al. (2005). "AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer". Genes Chromosomes Cancer 43 (3): 249–59. doi:10.1002/gcc.20188. PMID 15834940.
- Persson S, Rosenquist M, Knoblach B, et al. (2005). "Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family". Mol. Phylogenet. Evol. 36 (3): 734–40. doi:10.1016/j.ympev.2005.04.002. PMID 15935701.
- Fritzsche FR, Dahl E, Pahl S, et al. (2006). "Prognostic relevance of AGR2 expression in breast cancer". Clin. Cancer Res. 12 (6): 1728–34. doi:10.1158/1078-0432.CCR-05-2057. PMID 16551856.
- Zhang Y, Forootan SS, Liu D, et al. (2007). "Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients". Prostate Cancer Prostatic Dis. 10 (3): 293–300. doi:10.1038/sj.pcan.4500960. PMID 17457305.
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