Ajmaline
Oxford Dictionary of Biochemistry:
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ajmaline
ajmalan-17,20-diol; an alkaloid from the roots of Rauwolfia serpentina. It is used clinically as an antihypertensive and antiarrhythmic, having the effect of normalizing heart rhythm.
| air-lift bioreactor, ahnak, agropine | |
| akaryotic, al+, alamethicin |
Wikipedia on Answers.com:
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Ajmaline
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| Systematic (IUPAC) name | |
| (17R,21β)-ajmalan- 17,21-diol OR (1R,9R,10S,13R,14R,16S,18S)- 13-ethyl- 8-methyl- 8,15-diazahexacyclo [14.2.1.01,9.02,7.010,15.012,17] nonadeca- 2(7),3,5-triene- 14,18-diol |
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| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 4360-12-7  |
| ATC code | C01BA05 |
| PubChem | CID 20367 |
| DrugBank | DB01426 |
| ChemSpider | 10469368 |
| UNII | 1PON08459R |
| KEGG | D00199  |
| ChEMBL | CHEMBL1230919 |
| Chemical data | |
| Formula | C20H26N2O2 |
| Mol. mass | 326.433 g/mol |
| SMILES | eMolecules & PubChem |
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Ajmaline is an alkaloid that is class Ia antiarrhythmic agent. It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome.
The compound was first isolated by Salimuzzaman Siddiqui in 1931 [1] from the roots of Rauwolfia serpentina. He named it ajmaline, after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia.[2]
See also
References
- ^ Siddiqui, S.; Siddiqui, R. H. (1931). J. Indian Chem. Soc. 8: 667–80.
- ^ Ahmed Nasim Sandilvi (2003), Salimuzzaman Siddiqui: pioneer of scientific research in Pakistan. Daily Dawn. 12 April 2003. Retrieved on 19 July 2007.
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Oxford Dictionary of Biochemistry
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